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Destructive bone lesions have a negative impact on the quality of life of leukemia patients, causing unbearable pain and, in some cases, limb paralysis. However, the mechanism, by which leukemic cells produce destructive bone lesions, and the effect of therapeutics on osteolytic lesions have not been fully elucidated yet and, thus, stand to benefit from an<jats:italic>in vivo<\/jats:italic>model. To that end, HL-60 cells were transformed by retrovirus-mediated constitutively active (CA) STAT5 expression and injected into nonobese diabetic (NOD)\/SCID mice via the tail vein. After three weeks, lumbar spines were subjected to histocytometric analysis. Xenograft mice developed hind limb paralysis in 2-3 weeks, which was consistent with the consequences of spinal bone destruction by extramedullary invasion of leukemia cells. The<jats:italic>in vivo<\/jats:italic>model will improve the understanding and treatment of osteolytic bone lesions caused by myeloid leukemic cells.<\/jats:p>","DOI":"10.1155\/2017\/3521481","type":"journal-article","created":{"date-parts":[[2017,9,28]],"date-time":"2017-09-28T21:07:05Z","timestamp":1506632825000},"page":"1-6","source":"Crossref","is-referenced-by-count":2,"title":["<i>In Vivo<\/i>Murine Model of Leukemia Cell-Induced Spinal Bone Destruction"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1372-8450","authenticated-orcid":true,"given":"Jia-Jie","family":"Chen","sequence":"first","affiliation":[{"name":"Institute of Molecular Medicine, Health Science Center, Shenzhen University, Shenzhen 518060, China"},{"name":"Vaccine Research Institute of Sun Yat-sen University, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery and Joint Surgery, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"Cai","sequence":"additional","affiliation":[{"name":"Vaccine Research Institute of Sun Yat-sen University, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5344-4340","authenticated-orcid":true,"given":"Gang","family":"Chang","sequence":"additional","affiliation":[{"name":"Institute of Molecular Medicine, Health Science Center, Shenzhen University, Shenzhen 518060, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2014.07.268"},{"issue":"7","key":"2","first-page":"3025","volume":"17","year":"2016","journal-title":"Asian Pacific Journal of Cancer Prevention"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2012.57"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21349"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.639"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24074"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2007.09.001"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1163\/156855900300109576"},{"issue":"4","key":"9","first-page":"67","volume":"104","year":"2000","journal-title":"Revista Medico-Chirurgicala a Societatii De Medici Si Naturalisti Din Iasi"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.lrr.2013.07.002"},{"issue":"3","key":"11","first-page":"213","volume":"162","year":"1982","journal-title":"IMJ: Illinois Medical Journal"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.4084\/mjhid.2015.017"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-01-029918"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2004.12.010"},{"issue":"9","key":"15","doi-asserted-by":"crossref","first-page":"3852","DOI":"10.1182\/blood.V87.9.3852.bloodjournal8793852","volume":"87","year":"1996","journal-title":"Blood"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2008.18"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1038\/nri1995"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-10-4110"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-12-397554"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1586\/14737159.8.1.73"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1080\/08916930701694667"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-012-9405-5"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2017\/3521481.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2017\/3521481.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2017\/3521481.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,18]],"date-time":"2020-10-18T11:33:23Z","timestamp":1603020803000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/bmri\/2017\/3521481\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":22,"alternative-id":["3521481","3521481"],"URL":"https:\/\/doi.org\/10.1155\/2017\/3521481","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"type":"print","value":"2314-6133"},{"type":"electronic","value":"2314-6141"}],"subject":[],"published":{"date-parts":[[2017]]}}}