{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T06:38:31Z","timestamp":1773211111740,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Diabetes Action and Research Education Foundation"},{"name":"Soy Health Research Program"},{"name":"Midwestern University Intramural"},{"name":"Midwestern University DO Summer Fellow Program"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Intestinal dysfunction in the<jats:italic>ob\/ob<\/jats:italic>mouse model of diabetes mimics that seen clinically.<jats:italic>Methods<\/jats:italic>. We determined the effects of a 4-week genistein diet (600\u2009mg genistein\/kg food) on intestinal function (contractility, morphology, AChR, and motility) in female<jats:italic>ob\/ob<\/jats:italic>and lean mice.<jats:italic>Results<\/jats:italic>. Contractility of the jejunum in response to incrementally increasing concentrations of KCl was comparable in<jats:italic>ob\/ob<\/jats:italic>females and lean controls regardless of a genistein-diet. There were no changes in the wall thickness measured. We assessed the number of clusters of AChR in the jejunum wall; AChR were decreased by 48% in<jats:italic>ob\/ob<\/jats:italic>mice versus leans, and the genistein diet reversed this. In utilizing a video-imaging system to evaluate gastrointestinal motility, we determined that the distance between consecutive contractile events was significantly increased by 1.87-fold in<jats:italic>ob\/ob<\/jats:italic>mice versus leans, and the genistein diet was without effect.<jats:italic>Conclusions<\/jats:italic>. These data suggest that slowed intestinal transit in the diabetic<jats:italic>ob\/ob<\/jats:italic>mouse may be due in part to decreased AChR and decreased contraction events occurring per unit time. A genistein diet rescues the number of AChR to levels of leans yet did not change the number of contractile events. Feeding<jats:italic>ob\/ob<\/jats:italic>mice a genistein-rich diet has potential therapeutic benefits towards improving the debilitating diabetes-related gastrointestinal dysfunction.<\/jats:p>","DOI":"10.1155\/2017\/3568146","type":"journal-article","created":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T17:03:30Z","timestamp":1501607010000},"page":"1-9","source":"Crossref","is-referenced-by-count":9,"title":["Dietary Genistein Influences Number of Acetylcholine Receptors in Female Diabetic Jejunum"],"prefix":"10.1155","volume":"2017","author":[{"given":"Sydney","family":"Schacht","sequence":"first","affiliation":[{"name":"Department of Physiology, Midwestern University, 19555 N. 59th Avenue, Glendale, AZ 85308, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faisal","family":"Masood","sequence":"additional","affiliation":[{"name":"Department of Physiology, Midwestern University, 19555 N. 59th Avenue, Glendale, AZ 85308, 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