{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T16:18:39Z","timestamp":1788884319738,"version":"build-2803163510"},"reference-count":108,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Health Research Program of Hangzhou","award":["20140633B27"],"award-info":[{"award-number":["20140633B27"]}]},{"name":"Health Research Program of Hangzhou","award":["81570017"],"award-info":[{"award-number":["81570017"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["20140633B27"],"award-info":[{"award-number":["20140633B27"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570017"],"award-info":[{"award-number":["81570017"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>\n                    Glibenclamide is the most widely used sulfonylurea drug for the treatment of type 2 diabetes mellitus (DM). Recent studies have suggested that glibenclamide reduced adverse neuroinflammation and improved behavioral outcomes following central nervous system (CNS) injury. We reviewed glibenclamide\u2019s anti-inflammatory effects: abundant evidences have shown that glibenclamide exerted an anti-inflammatory effect in respiratory, digestive, urological, cardiological, and CNS diseases, as well as in ischemia-reperfusion injury. Glibenclamide might block K\n                    <jats:sub>ATP<\/jats:sub>\n                    channel, Sur1-Trpm4 channel, and NOD-like receptor pyrin domain containing 3 (NLRP3) inflammasome activation, decrease the production of proinflammatory mediators (TNF-\n                    <jats:italic>\u03b1<\/jats:italic>\n                    , IL-1\n                    <jats:italic>\u03b2<\/jats:italic>\n                    , and reactive oxygen species), and suppress the accumulation of inflammatory cells. Glibenclamide\u2019s anti-inflammation warrants further investigation.\n                  <\/jats:p>","DOI":"10.1155\/2017\/3578702","type":"journal-article","created":{"date-parts":[[2017,6,27]],"date-time":"2017-06-27T17:02:18Z","timestamp":1498582938000},"page":"1-11","source":"Crossref","is-referenced-by-count":71,"title":["A Protective Role of Glibenclamide in Inflammation-Associated Injury"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9298-3961","authenticated-orcid":true,"given":"Gensheng","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuhui","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 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