{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:59:59Z","timestamp":1777420799475,"version":"3.51.4"},"reference-count":47,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computational and Mathematical Methods in Medicine"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>This study was designed to identify attractor modules and further reveal the potential biological processes involving in sevoflurane-induced anesthesia in patients treated with coronary artery bypass graft (CABG) surgery. Microarray profile data (ID: E-GEOD-4386) on atrial samples obtained from patients receiving anesthetic gas sevoflurane prior to and following CABG procedure were downloaded from EMBL-EBI database for further analysis. Protein-protein interaction (PPI) networks of baseline and sevoflurane groups were inferred and reweighted according to Spearman correlation coefficient (SCC), followed by systematic modules inference using clique-merging approach. Subsequently,<jats:italic>attract<\/jats:italic>method was utilized to explore attractor modules. Finally, pathway enrichment analyses for genes in the attractor modules were implemented to illuminate the biological processes in sevoflurane group. Using clique-merging approach, 27 and 36 modules were obtained from the PPI networks of baseline and sevoflurane-treated samples, respectively. By comparing with the baseline condition, 5 module pairs with the same gene composition were identified. Subsequently, 1 out of 5 modules was identified as an attractor based on<jats:italic>attract<\/jats:italic>method. Additionally, pathway analysis indicated that genes in the attractor module were associated with neuroactive ligand-receptor interaction. Accordingly, sevoflurane might exert important functions in cardioprotection in patients following CABG, partially through regulating the pathway of neuroactive ligand-receptor interaction.<\/jats:p>","DOI":"10.1155\/2017\/3618213","type":"journal-article","created":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:37:10Z","timestamp":1488328630000},"page":"1-7","source":"Crossref","is-referenced-by-count":14,"title":["Cardioprotection Effects of Sevoflurane by Regulating the Pathway of Neuroactive Ligand-Receptor Interaction in Patients Undergoing Coronary Artery Bypass Graft Surgery"],"prefix":"10.1155","volume":"2017","author":[{"given":"Jinquan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Southwest Hospital, Chongqing 400038, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The People\u2019s Hospital of Bishan County, Chongqing 402760, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Southwest Hospital, Chongqing 400038, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5271-000X","authenticated-orcid":true,"given":"Xiaojun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Southwest Hospital, Chongqing 400038, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007224.pub2"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000109489.71945.bd"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200201000-00025"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aep141"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2011.02405.x"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.3109\/14017431.2012.760749"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200201000-00025"},{"issue":"2","key":"8","first-page":"105","volume":"2","year":"2010","journal-title":"HSR Proceedings in Intensive Care & Cardiovascular Anesthesia"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aei026"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1007\/bf03022834"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2007.02.013"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts564"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1093\/bfgp\/els035"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1142\/S0219720008003497"},{"key":"15","first-page":"138","volume":"21","year":"2008","journal-title":"Genome Informatics"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp311"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1002690"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1186\/1752-0509-2-56"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt191"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt569"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1504\/ijdmb.2015.067323"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200703000-00008"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks1094"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.2478\/v10117-011-0021-1"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1142\/S021972001230002X"},{"issue":"10","key":"26","first-page":"669","volume":"110","year":"2009","journal-title":"Bratislavsk\u00e9 Lek\u00e1rske Listy"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025445"},{"issue":"1","key":"28","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","volume":"57","year":"1995","journal-title":"Journal of the Royal Statistical Society. 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