{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:30:24Z","timestamp":1790184624318,"version":"4.1.0"},"reference-count":57,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003663","name":"Korea Small and Medium Business Administration","doi-asserted-by":"crossref","award":["S2435140"],"award-info":[{"award-number":["S2435140"]}],"id":[{"id":"10.13039\/501100003663","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>Although osteoarthritis (OA), a degenerative joint disease characterized by the degradation of joint articular cartilage and subchondral bones, is generally regarded as a degenerative rather than inflammatory disease, recent studies have indicated the involvement of inflammation in OA pathogenesis. <jats:italic>Tabebuia avellanedae<\/jats:italic> has long been used to treat various diseases; however, its role in inflammatory response and the underlying molecular mechanisms remain poorly understood. In this study, the pharmacological effects of Tabetri (<jats:italic>Tabebuia avellanedae<\/jats:italic> ethanol extract (Ta-EE)) on OA pathogenesis induced by monoiodoacetate (MIA) and the underlying mechanisms were investigated using experiments with a rat model and <jats:italic>in vitro<\/jats:italic> cellular models. In the animal model, Ta-EE significantly ameliorated OA symptoms and reduced the serum levels of inflammatory mediators and proinflammatory cytokines without any toxicity. The anti-inflammatory activity of Ta-EE was further confirmed in a macrophage-like cell line (RAW264.7). Ta-EE dramatically suppressed the production and mRNA expressions of inflammatory mediators and proinflammatory cytokines in lipopolysaccharide-stimulated RAW264.7 cells without any cytotoxicity. Finally, the chondroprotective effect of Ta-EE was examined in a chondrosarcoma cell line (SW1353). Ta-EE markedly suppressed the mRNA expression of matrix metalloproteinase genes. The anti-inflammatory and chondroprotective activities of Ta-EE were attributed to the targeting of the nuclear factor-kappa B (NF-<jats:italic>\u03ba<\/jats:italic>B) and activator protein-1 (AP-1) signaling pathways in macrophages and chondrocytes.<\/jats:p>","DOI":"10.1155\/2017\/3619879","type":"journal-article","created":{"date-parts":[[2017,11,26]],"date-time":"2017-11-26T18:31:12Z","timestamp":1511721072000},"page":"1-14","source":"Crossref","is-referenced-by-count":19,"title":["Tabetri\u2122 (<i>Tabebuia avellanedae<\/i> Ethanol Extract) Ameliorates Osteoarthritis Symptoms Induced by Monoiodoacetate through Its Anti-Inflammatory and Chondroprotective Activities"],"prefix":"10.1155","volume":"2017","author":[{"given":"Jae Gwang","family":"Park","sequence":"first","affiliation":[{"name":"Department of Genetic Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7166-3659","authenticated-orcid":true,"given":"Young-Su","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Engineering, Cheongju University, Cheongju 28503, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yo Han","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Genetic Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sulgi","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Genetic Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Yun","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Genetic Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1908-5310","authenticated-orcid":true,"given":"Eunji","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Genetic Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong-Gu","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Genetic Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adithan","family":"Aravinthan","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Chonbuk National University, Iksan 54596, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang Soo","family":"Baik","sequence":"additional","affiliation":[{"name":"R&I Planning Department, Nutribiotech Co. 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