{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T19:26:52Z","timestamp":1748978812154,"version":"3.37.3"},"reference-count":49,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001862","name":"Svenska Forskningsr\u00e5det Formas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001862","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Family Olinder-Nielsen\u2019s Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p><jats:italic>Chlamydia pneumoniae (C. pneumoniae)<\/jats:italic> may be a mediator in the pathogenesis of atherosclerosis. For its growth<jats:italic> C. pneumoniae<\/jats:italic> depends on iron (Fe), but how Fe changes in tissues during persistent infection or affects bacterial replication in tissues is unknown.<jats:italic> C. pneumoniae<\/jats:italic>-infected C57BL\/6J mice were sacrificed on days 4, 8, 20, and 40. Mice had bacteria in the lungs and liver on all days. Inflammatory markers, chemokine<jats:italic> Cxcl2<\/jats:italic> and<jats:italic> interferon-gamma<\/jats:italic>, were not affected in the liver on day 40. The copper (Cu)\/zinc (Zn) ratio in serum, another marker of infection\/inflammation, increased on day 4 and tended to increase again on day 40. The Fe markers, transferrin receptor (TfR), Hepcidin (Hamp1), and ferroportin 1 (Fpn1), increased in the liver on day 4 and then normalized except for TfR that tended to decrease. TfR responses were similar to Fe in serum that increased on day 4 but tended to decrease thereafter. In the liver, Fe was increased on day 4 and also on day 40. The reappearing increases in Cu\/Zn on day 40 concomitant with the increase in liver Fe on day 40, even though<jats:italic> TfR<\/jats:italic> tended to decrease, and the fact that viable<jats:italic> C. pneumoniae<\/jats:italic> was present in the lungs and liver may indicate the early phase of activation of recurrent infection.<\/jats:p>","DOI":"10.1155\/2017\/3642301","type":"journal-article","created":{"date-parts":[[2017,6,13]],"date-time":"2017-06-13T17:03:26Z","timestamp":1497373406000},"page":"1-8","source":"Crossref","is-referenced-by-count":3,"title":["Iron Homeostasis in Tissues Is Affected during Persistent<i> Chlamydia pneumoniae<\/i> Infection in Mice"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2845-9190","authenticated-orcid":true,"given":"Marie","family":"Edvinsson","sequence":"first","affiliation":[{"name":"Department of Medical Sciences, Section of Infectious Diseases, Uppsala University, Uppsala, 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