{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T05:19:31Z","timestamp":1761110371931,"version":"3.37.3"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ningbo Social and Scientific Development Fund","award":["2012C50006","2015C50012","2016A610132","2017A610250"],"award-info":[{"award-number":["2012C50006","2015C50012","2016A610132","2017A610250"]}]},{"name":"Ningbo Social and Scientific Development Fund","award":["2012C50006","2015C50012","2016A610132","2017A610250"],"award-info":[{"award-number":["2012C50006","2015C50012","2016A610132","2017A610250"]}]},{"DOI":"10.13039\/100007834","name":"Natural Science Foundation of Ningbo","doi-asserted-by":"publisher","award":["2012C50006","2015C50012","2016A610132","2017A610250"],"award-info":[{"award-number":["2012C50006","2015C50012","2016A610132","2017A610250"]}],"id":[{"id":"10.13039\/100007834","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007834","name":"Natural Science Foundation of Ningbo","doi-asserted-by":"publisher","award":["2012C50006","2015C50012","2016A610132","2017A610250"],"award-info":[{"award-number":["2012C50006","2015C50012","2016A610132","2017A610250"]}],"id":[{"id":"10.13039\/100007834","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Canadian Respiratory Journal"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. We evaluated the utility of galactomannan (GM) in bronchoalveolar lavage fluid (BALF) for the diagnosis of invasive pulmonary aspergillosis (IPA) in nonneutropenic patients.<jats:italic> Methods<\/jats:italic>. A total of 183 patients were included in the final analysis. Bronchoscopies and the detection of GM in BALF were all performed on them.<jats:italic> Results<\/jats:italic>. Ten cases of IPA were diagnosed. ROC data demonstrated that, for diagnosing IPA, an optimal cutoff value for GM in BALF of 0.76 yielded a sensitivity of 100.0% and a specificity of 76.2%. Symptoms and radiological findings had no significant difference between proven or probable IPA group and non-IPA group. In our case-control analysis, although nine patients with false-positive results received treatment with Piperacillin\/tazobactam, there was no significant difference between case and control group.<jats:italic> Conclusions<\/jats:italic>. BALF GM detection is a valuable adjunctive diagnostic tool. Our retrospective study suggests that the optimal value of GM detection in BALF is 0.76 in nonneutropenic patients.<\/jats:p>","DOI":"10.1155\/2017\/3685261","type":"journal-article","created":{"date-parts":[[2017,11,13]],"date-time":"2017-11-13T18:31:22Z","timestamp":1510597882000},"page":"1-7","source":"Crossref","is-referenced-by-count":15,"title":["Galactomannan in Bronchoalveolar Lavage Fluid for Diagnosis of Invasive Pulmonary Aspergillosis with Nonneutropenic Patients"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5585-0980","authenticated-orcid":true,"given":"Qidong","family":"Zhuang","sequence":"first","affiliation":[{"name":"Department of Pulmonology, The Affiliated Hospital of Ningbo University, 247 Renmin Road, Ningbo, Zhejiang 315020, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongying","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, The Affiliated Hospital of Ningbo University, 247 Renmin Road, Ningbo, Zhejiang 315020, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, The Affiliated Hospital of Ningbo University, 247 Renmin Road, Ningbo, Zhejiang 315020, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, The Affiliated Hospital of Ningbo University, 247 Renmin Road, Ningbo, Zhejiang 315020, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Microbiology, The Affiliated Hospital of Ningbo University, 247 Renmin Road, Ningbo, Zhejiang 315020, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Microbiology, The 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