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The hallmarks of AD are accumulation of the amyloid-<jats:italic>\u03b2<\/jats:italic>peptide 1\u201342 (A<jats:italic>\u03b2<\/jats:italic>42) and abnormal hyperphosphorylation of Tau (p-Tau) protein in different areas of the brain and, more recently reported, in the visual cortex. Recently, A<jats:italic>\u03b2<\/jats:italic>42 peptide overproduction has been involved in visual loss. Similar to AD, in normal aging, there is a significant amyloid deposition related to the overactivation of the aforementioned mechanisms. However, the mechanisms associated with visual loss secondary to age-induced visual cortex affectation are not completely understood. Young and aged mice were used as model to analyze the presence of A<jats:italic>\u03b2<\/jats:italic>42, p-Tau, glial-acidic fibrillary protein (GFAP), and presenilin-2, one of the main enzymes involved in A<jats:italic>\u03b2<\/jats:italic>42 production. Our results show a significant increase of A<jats:italic>\u03b2<\/jats:italic>42 deposition in aged mice in the following cells and\/or tissues: endothelial cells and blood vessels and neurons of the visual cortex; they also show an increase of the expression of GFAP and presenilin-2 in this region. These results provide a comprehensive framework for the role of A<jats:italic>\u03b2<\/jats:italic>42 in visual loss due to inflammation present with aging and offer some clues for fruitful avenues for the study of healthy aging.<\/jats:p>","DOI":"10.1155\/2017\/3706018","type":"journal-article","created":{"date-parts":[[2017,9,12]],"date-time":"2017-09-12T21:06:27Z","timestamp":1505250387000},"page":"1-10","source":"Crossref","is-referenced-by-count":9,"title":["Markers of Alzheimer\u2019s Disease in Primary Visual Cortex in Normal Aging in Mice"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5098-367X","authenticated-orcid":true,"given":"Luis Fernando","family":"Hern\u00e1ndez-Zimbr\u00f3n","sequence":"first","affiliation":[{"name":"Research Department, Asociaci\u00f3n para Evitar la Ceguera en M\u00e9xico, \u201cHospital Dr. Luis Sanchez Bulnes\u201d IAP, 04030 M\u00e9xico City, 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