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We evaluated whether circulating APN level is an independent predictor of composite outcome: death, left ventricle assist device (LVAD) implantation, and heart transplantation (HT) in patients with nonischemic DCM. 57 patients with nonischemic DCM (average LV diastolic diameter 6.85\u2009cm, LV ejection fraction 26.63%, and pulmonary capillary wedge pressure 22.06\u2009\u2009mmHg) were enrolled. Patients underwent echocardiography, right heart catheterization, and endomyocardial biopsy. During a mean follow-up of 33.42 months, 15 (26%) patients died, 12 (21%) patients underwent HT, and 8 (14%) patients were implanted with LVAD. APN level was significantly higher in patients who experienced study endpoints (23.4 versus 10.9\u2009ug\/ml, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.01<\/mml:mn><\/mml:math>). APN was associated with worse outcome in univariate Cox proportional hazards model (HR 1.04, CI 1.02\u20131.07, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.001<\/mml:mn><\/mml:math>) but lost significance adjusting for other covariates. Average global strain (AGS) is an independent outcome predictor (HR 1.42, CI 1.081\u20131.866, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.012<\/mml:mn><\/mml:math>). Increased circulating APN level was associated with higher mortality and may be an additive prognostic marker in DCM with advanced HF. Combination of serum (APN, BNP, TNF-<jats:italic>\u03b1<\/jats:italic>) and echocardiographic (AGS) markers may increase the HF predicting power for the nonischemic DCM patients.<\/jats:p>","DOI":"10.1155\/2017\/3818292","type":"journal-article","created":{"date-parts":[[2017,11,26]],"date-time":"2017-11-26T18:31:19Z","timestamp":1511721079000},"page":"1-13","source":"Crossref","is-referenced-by-count":16,"title":["The Role of Serum Adiponectin for Outcome Prediction in Patients with Dilated Cardiomyopathy and Advanced Heart Failure"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3145-2662","authenticated-orcid":true,"given":"Vaida","family":"Baltr\u016bnien\u0117","sequence":"first","affiliation":[{"name":"Department of Pathology, Forensic Medicine and Pharmacology, Faculty of Medicine, Vilnius University, M. K. Ciurlionio 21, LT-03101 Vilnius, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daiva","family":"Bironait\u0117","sequence":"additional","affiliation":[{"name":"Department of Regenerative Medicine, State Research Institute, Center for Innovative Medicine, Santariskiu 5, LT-08406 Vilnius, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0619-3881","authenticated-orcid":true,"given":"Ieva","family":"Ka\u017eukauskien\u0117","sequence":"additional","affiliation":[{"name":"Department of Pathology, Forensic Medicine and Pharmacology, Faculty of Medicine, Vilnius University, M. K. 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Ciurlionio 21, LT-03101 Vilnius, Lithuania"},{"name":"Department of Integrative Pathophysiology, Medical Faculty Mannheim, Mannheim, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0912-4125","authenticated-orcid":true,"given":"Dalius","family":"Vitkus","sequence":"additional","affiliation":[{"name":"Department of Physiology, Biochemistry, Microbiology and Laboratory Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K\u0119stutis","family":"Ru\u010dinskas","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology, Vilnius University Hospital Santaros Klinikos, Santariskiu 2, LT-08661 Vilnius, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4849-5180","authenticated-orcid":true,"given":"Edvardas","family":"\u017durauskas","sequence":"additional","affiliation":[{"name":"Department of Pathology, Forensic Medicine and Pharmacology, Faculty of Medicine, Vilnius University, M. 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