{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T11:58:20Z","timestamp":1790855900660,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Coloplast A\/S"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastroenterology Research and Practice"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p><jats:italic>Background.<\/jats:italic> Transanal irrigation (TAI) can successfully treat neurogenic bowel dysfunction (NBD), but patient perception of its use in chronic idiopathic constipation (CIC) is unknown.<jats:italic> Objective.<\/jats:italic> To evaluate patient perceptions of the efficacy and safety of TAI for CIC and whether there are predictive factors of perceived treatment response.<jats:italic> Methods.<\/jats:italic> Prospective data collection of baseline physiology and symptom severity; retrospective evaluation of efficacy and safety perceptions using a snapshot survey. All patients fulfilling the Rome III criteria for functional constipation with chronic idiopathic aetiology were included. The main outcome measure was the duration of patients\u2019 usage of TAI.<jats:italic> Results.<\/jats:italic> 102 patients reported 21,476 irrigations over 119 patient years, with a mean duration of therapy use of 60.5 weeks [SD 73.2\u2009:\u2009SE 7.3]. Overall symptom improvement included general well-being (65%), rectal clearance (63%), bloating (49%), abdominal pain (48%), and bowel frequency (42%). 68 patients (67%) were \u201cmoderately better\u201d or \u201cvery much better\u201d on a satisfaction question. Reported complications were minor. No correlation was demonstrated between duration of therapy use and baseline measures.<jats:italic> Conclusion.<\/jats:italic> A significant proportion of CIC sufferers use TAI as a long-term or bridging therapy and perceive it as safe. This therapy demands a prospective investigation of efficacy and safety.<\/jats:p>","DOI":"10.1155\/2017\/3826087","type":"journal-article","created":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T16:00:59Z","timestamp":1483286459000},"page":"1-6","source":"Crossref","is-referenced-by-count":29,"title":["Transanal Irrigation for Refractory Chronic Idiopathic Constipation: Patients Perceive a Safe and Effective Therapy"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1133-5792","authenticated-orcid":true,"given":"Kevin J.","family":"Etherson","sequence":"first","affiliation":[{"name":"Department of Colorectal Surgery, County Durham and Darlington NHS Foundation Trust, Durham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Minty","sequence":"additional","affiliation":[{"name":"Department of Radiology, County Durham and Darlington NHS Foundation Trust, Durham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iain M.","family":"Bain","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, County Durham and Darlington NHS Foundation Trust, Durham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Cundall","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, County Durham and Darlington NHS Foundation Trust, Durham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Yiannakou","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, County Durham and Darlington NHS Foundation Trust, Durham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","year":"2006"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9270(99)00701-7"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9270(02)04199-0"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04273.x"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1007\/s11845-011-0756-7"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03370.x"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2008.03806.x"},{"key":"8","volume":"60, article a160","year":"2011","journal-title":"Gut"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1038\/sc.2013.86"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.3109\/00365520903583855"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1007\/DCR.0b013e3181979341"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2004.00696.x"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1007\/bf01303162"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1080\/003655299750025327"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(87)90837-7"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1038\/sc.2008.98"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.06.004"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.12968\/bjon.2007.16.14.24323"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-004-6498-0"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1136\/gut.43.3.388"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1007\/DCR.0b013e3181dcb2d6"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00101.2011"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.10.028"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2011.01709.x"}],"container-title":["Gastroenterology Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/grp\/2017\/3826087.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/grp\/2017\/3826087.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/grp\/2017\/3826087.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T16:01:01Z","timestamp":1483286461000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/grp\/2017\/3826087\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":24,"alternative-id":["3826087","3826087"],"URL":"https:\/\/doi.org\/10.1155\/2017\/3826087","relation":{},"ISSN":["1687-6121","1687-630X"],"issn-type":[{"value":"1687-6121","type":"print"},{"value":"1687-630X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}