{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:44:25Z","timestamp":1790631865222,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003443","name":"Ministry of Education and Science of the Russian Federation","doi-asserted-by":"publisher","award":["RFMEFI60714X0016"],"award-info":[{"award-number":["RFMEFI60714X0016"]}],"id":[{"id":"10.13039\/501100003443","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>Previously transgenic <jats:italic>Kalanchoe pinnata<\/jats:italic> plants producing an antimicrobial peptide cecropin P1 (CecP1) have been reported. Now we report biological testing <jats:italic>K. pinnata<\/jats:italic> extracts containing CecP1 as a candidate drug for treatment of wounds infected with <jats:italic>Candida albicans.<\/jats:italic> The drug constitutes the whole juice from <jats:italic>K. pinnata<\/jats:italic> leaves (not ethanol extract) sterilized with nanofiltration. A microbicide activity of CecP1 against an animal fungal pathogen in vivo was demonstrated for the first time. However, a favorable therapeutic effect of the transgenic <jats:italic>K. pinnata<\/jats:italic> extract was attributed to a synergism between the fungicide activity of CecP1 and wound healing (antiscar), revascularizing, and immunomodulating effect of natural biologically active components of <jats:italic>K. pinnata<\/jats:italic>. A commercial fungicide preparation clotrimazole eliminated <jats:italic>C. albicans<\/jats:italic> cells within infected wounds in rats with efficiency comparable to CecP1-enriched <jats:italic>K. pinnata<\/jats:italic> extract. But in contrast to <jats:italic>K. pinnata<\/jats:italic> extract, clotrimazole did not exhibit neither wound healing activity nor remodeling of the scar matrix. Taken together, our results allow assumption that CecP1-enriched <jats:italic>K. pinnata<\/jats:italic> extracts should be considered as a candidate drug for treatment of dermatomycoses, wounds infected with fungi, and bedsores.<\/jats:p>","DOI":"10.1155\/2017\/3940743","type":"journal-article","created":{"date-parts":[[2017,6,11]],"date-time":"2017-06-11T17:02:31Z","timestamp":1497200551000},"page":"1-9","source":"Crossref","is-referenced-by-count":19,"title":["Immunomodulating and Revascularizing Activity of <i>Kalanchoe pinnata<\/i> Synergize with Fungicide Activity of Biogenic Peptide Cecropin P1"],"prefix":"10.1155","volume":"2017","author":[{"given":"N. S.","family":"Zakharchenko","sequence":"first","affiliation":[{"name":"Branch of Shemyakin-Ovchinnikov Institute of Bioorganic \u0421hemistry, Russian Academy of Sciences, Science Avenue 6, Pushchino, Moscow Region 142290, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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