{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T14:57:56Z","timestamp":1740149876404,"version":"3.37.3"},"reference-count":42,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81501086"],"award-info":[{"award-number":["81501086"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastroenterology Research and Practice"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. This study aimed to determine whether the treatment of a long-acting formulation of octreotide (OCT-LAR) exerted a similar effect on improving the prognosis of patients with portal hypertension compared with placement of transjugular intrahepatic portosystemic shunts (TIPSs).<jats:italic>Methods<\/jats:italic>. A total of 24 patients with portal hypertension who underwent TIPS placement or OCT-LAR treatment from January 2010 to January 2015 were reviewed. Hemodynamic studies, biological values, live functions, and treatment complications before and during the treatment were evaluated.<jats:italic>Results<\/jats:italic>. Baseline clinical characteristics were similar between two groups. Hepatic venous pressure gradient (HVPG) was improved in OCT-LAR groups (15.9\u2009\u00b1\u20092.4 to 12.8\u2009\u00b1\u20091.6\u2009mmHg). Both groups showed a slight decrease in endothelin-1 (ET-1) and urotensin II and a slight increase in oxide metabolite (NO<jats:italic>x<\/jats:italic>) concentrations with no significant difference. Aspartate aminotransferase and alanine aminotransferase increased one week after TIPS placement when they improved in the OCT-LAR treatment group. The complications of OCT-LAR treatment were minor and transient. However, one patient who received TIPS placement presented procedure-related complications and required rehospitalization, and 2 patients had developed hepatic encephalopathy during the follow-up period.<jats:italic>Conclusion<\/jats:italic>. Prolonged administration of OCT-LAR exerted a virtually similar effect on improving hemodynamic parameters and liver function in patients with portal hypertension compared with placement of TIPS, with no apparent serious adverse effects.<\/jats:p>","DOI":"10.1155\/2017\/3943210","type":"journal-article","created":{"date-parts":[[2017,8,10]],"date-time":"2017-08-10T21:02:34Z","timestamp":1502398954000},"page":"1-6","source":"Crossref","is-referenced-by-count":1,"title":["Effects of a Long-Acting Formulation of Octreotide on Patients with Portal Hypertension"],"prefix":"10.1155","volume":"2017","author":[{"given":"Pei-Jing","family":"Cui","sequence":"first","affiliation":[{"name":"Department of Geriatrics, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200233, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Surgery, Shanghai Jiao Tong University Affiliated Sixth People\u2019s Hospital, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yin","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Surgery, Shanghai Jiao Tong University Affiliated Sixth People\u2019s Hospital, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng-Yun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Surgery, Shanghai Jiao Tong University Affiliated Sixth People\u2019s Hospital, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1008-0388","authenticated-orcid":true,"given":"Jun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Surgery, Shanghai Jiao Tong University Affiliated Sixth People\u2019s Hospital, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"issue":"3","key":"1","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1002\/hep.21907","volume":"46","year":"2007","journal-title":"Hepatology"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.03.007"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.03.007"},{"issue":"4","key":"4","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/0016-5085(81)90144-X","volume":"80","year":"1981","journal-title":"Gastroenterology"},{"issue":"5, part 1","key":"5","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/S0016-5085(82)80264-3","volume":"82","year":"1982","journal-title":"Gastroenterology"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.140.4.709"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i45.16996"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-941447"},{"key":"9","first-page":"III1","volume":"46","year":"2000","journal-title":"Gut"},{"issue":"5","key":"10","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1002\/hep.1840160513","volume":"16","year":"1992","journal-title":"Hepatology"},{"issue":"1","key":"11","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/S0168-8278(94)80142-8","volume":"21","year":"1994","journal-title":"Journal of Hepatology"},{"issue":"4","key":"12","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1053\/gast.2001.22451","volume":"120","year":"2001","journal-title":"Gastroenterology"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000000540"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01262.x"},{"key":"15","first-page":"1","volume":"1","year":"1964","journal-title":"Major Problems in Clinical Surgery"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2011.10.015"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20062"},{"issue":"8-9","key":"18","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/S0399-8320(06)73376-0","volume":"30","year":"2006","journal-title":"Gastroent\u00e9rologie Clinique et Biologique"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20070"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.06.004"},{"issue":"1","key":"21","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1001\/archsurg.136.1.17","volume":"136","year":"2001","journal-title":"Archives of Surgery"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1002\/lt.23775"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0910102"},{"issue":"8872","key":"24","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/0140-6736(93)91758-E","volume":"342","year":"1993","journal-title":"Lancet"},{"issue":"10","key":"25","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1136\/gut.2004.042002","volume":"53","year":"2004","journal-title":"Gut"},{"issue":"7119","key":"26","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1136\/bmj.315.7119.1338","volume":"315","year":"1997","journal-title":"British Medical Journal"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510310304"},{"key":"28","first-page":"S216","volume":"31","year":"1999","journal-title":"Italian Journal of Gastroenterology and Hepatology"},{"issue":"1","key":"29","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1053\/gast.2001.21619","volume":"120","year":"2001","journal-title":"Gastroenterology"},{"issue":"6","key":"30","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1517\/14740330903379525","volume":"8","year":"2009","journal-title":"Expert Opinion on Drug Safety"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.1997.v25.ajhep0250245"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2004.01.017"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2009.01.014"},{"issue":"6","key":"34","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1002\/hep.1840160624","volume":"16","year":"1992","journal-title":"Hepatology"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e318150d3b5"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1007\/s00270-008-9435-0"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.13.12232"},{"issue":"1","key":"38","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/hep.510250102","volume":"25","year":"1997","journal-title":"Hepatology"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2015.05.025"},{"issue":"6750","key":"40","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/45809","volume":"401","year":"1999","journal-title":"Nature"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2007.01539.x"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2012.05050.x"}],"container-title":["Gastroenterology Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/grp\/2017\/3943210.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/grp\/2017\/3943210.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/grp\/2017\/3943210.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T21:15:11Z","timestamp":1602710111000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/grp\/2017\/3943210\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":42,"alternative-id":["3943210","3943210"],"URL":"https:\/\/doi.org\/10.1155\/2017\/3943210","relation":{},"ISSN":["1687-6121","1687-630X"],"issn-type":[{"type":"print","value":"1687-6121"},{"type":"electronic","value":"1687-630X"}],"subject":[],"published":{"date-parts":[[2017]]}}}