{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:10:03Z","timestamp":1790838603296,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,8,24]],"date-time":"2017-08-24T00:00:00Z","timestamp":1503532800000},"content-version":"vor","delay-in-days":235,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P20GM104932"],"award-info":[{"award-number":["P20GM104932"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p><jats:italic>Renealmia alpinia<\/jats:italic> (Zingiberaceae), a medicinal plant of tropical rainforests, is used to treat snakebites and other injuries and also as a febrifuge, analgesic, antiemetic, antiulcer, and anticonvulsant. The dichloromethane extract of <jats:italic>R. alpinia<\/jats:italic> leaves showed potent inhibition of human monoamine oxidases\u2010 (MAOs\u2010) A and B. Phytochemical studies yielded six known compounds, including pinostrobin <jats:bold>1<\/jats:bold>, 4\u2032\u2010methyl ether sakuranetin <jats:bold>2<\/jats:bold>, sakuranetin <jats:bold>3<\/jats:bold>, pinostrobin chalcone <jats:bold>4<\/jats:bold>, yashabushidiol A <jats:bold>5<\/jats:bold>, and desmethoxyyangonin <jats:bold>6<\/jats:bold>. Compound <jats:bold>6<\/jats:bold> displayed about 30\u2010fold higher affinity for MAO\u2010B than MAO\u2010A, with Ki values of 31 and 922\u2009nM, respectively. Kinetic analysis of inhibition and equilibrium\u2010dialysis dissociation assay of the enzyme\u2010inhibitor complex showed reversible binding of desmethoxyyangonin <jats:bold>6<\/jats:bold> with MAO\u2010A and MAO\u2010B. The binding interactions of compound <jats:bold>6<\/jats:bold> in the active site of the MAO\u2010A and MAO\u2010B isoenzymes, investigated through molecular modeling algorithms, confirmed preferential binding of desmethoxyyangonin <jats:bold>6<\/jats:bold> with MAO\u2010B compared to MAO\u2010A. Selective reversible inhibitors of MAO\u2010B, like desmethoxyyangonin <jats:bold>6,<\/jats:bold> may have important therapeutic significance for the treatment of neurodegenerative disorders, such as Parkinson\u2019s disease and Alzheimer\u2019s disease.<\/jats:p>","DOI":"10.1155\/2017\/4018724","type":"journal-article","created":{"date-parts":[[2017,8,24]],"date-time":"2017-08-24T21:09:13Z","timestamp":1503608953000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Interactions of Desmethoxyyangonin, a Secondary Metabolite from <i>Renealmia alpinia<\/i>, with Human Monoamine Oxidase\u2010A and Oxidase\u2010B"],"prefix":"10.1155","volume":"2017","author":[{"given":"Narayan D.","family":"Chaurasiya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5064-2381","authenticated-orcid":false,"given":"Francisco","family":"Le\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanqing","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"G\u00f3mez-Betancur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dora","family":"Benjumea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0683-2209","authenticated-orcid":false,"given":"Larry A.","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Cutler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5421-1258","authenticated-orcid":false,"given":"Babu L.","family":"Tekwani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,24]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ympev.2007.06.007"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/tax.602010"},{"key":"e_1_2_9_3_2","first-page":"1","article-title":"Medicinal plants of Aguambu-Bamumbu in the Lebialem highlands, Southwest Province of Cameroon","volume":"3","author":"Focho D. 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