{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T05:29:27Z","timestamp":1773725367126,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>Resveratrol (RESV), an antifungal compound from grapes and other plants, has a distinct ability to inhibit the<jats:italic>Chlamydia (C.) trachomatis<\/jats:italic>developmental cycle in McCoy cells, a classic cell line used for chlamydial research. Inoculation of<jats:italic>C. trachomatis<\/jats:italic>with increasing amounts of RESV (from 12.5 to 100\u2009<jats:italic>\u03bc<\/jats:italic>M) gave a dose-dependent reduction in the number of infected McCoy cells visualized by using monoclonal antibodies against chlamydial lipopolysaccharide. A similar trend has been observed with immunoassay for major outer membrane protein (MOMP). Furthermore, there was a step-wise reduction in the number of<jats:italic>C. trachomatis<\/jats:italic>infective progenies caused by the increasing concentrations of RESV. The ability of RESV to arrest<jats:italic>C. trachomatis<\/jats:italic>growth in McCoy cells was confirmed by a nucleic acid amplification protocol which revealed dose-dependent changes in mRNAs for different genes of chlamydial developmental cycle (<jats:italic>euo<\/jats:italic>,<jats:italic>incA<\/jats:italic>, and<jats:italic>omcB<\/jats:italic>). Although the precise nature of the antichlamydial activity of RESV is yet to be determined and evaluated in future studies, the observed effect of RESV on<jats:italic>C. trachomatis<\/jats:italic>infection was not related to its potential effect on attachment\/entry of the pathogen into eukaryotic cells or RESV toxicity to McCoy cells. Similar inhibitory effect was shown for<jats:italic>C. pneumoniae<\/jats:italic>and<jats:italic>C. muridarum<\/jats:italic>.<\/jats:p>","DOI":"10.1155\/2017\/4064071","type":"journal-article","created":{"date-parts":[[2017,11,29]],"date-time":"2017-11-29T23:30:46Z","timestamp":1511998246000},"page":"1-7","source":"Crossref","is-referenced-by-count":16,"title":["Resveratrol Inhibits Propagation of<i>Chlamydia trachomatis<\/i>in McCoy Cells"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8201-6863","authenticated-orcid":true,"given":"Ivan M.","family":"Petyaev","sequence":"first","affiliation":[{"name":"Lycotec Ltd., Granta Park, Cambridge CB21 6GP, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nayilia A.","family":"Zigangirova","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Gamaleya Federal Research Center of Epidemiology and Microbiology, Ministry of Health, 18 Gamaleya Str., Moscow 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