{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T07:09:42Z","timestamp":1789024182420,"version":"build-2803163510"},"reference-count":47,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008212","name":"College of Medicine, Drexel University","doi-asserted-by":"publisher","award":["T32 MH079785"],"award-info":[{"award-number":["T32 MH079785"]}],"id":[{"id":"10.13039\/100008212","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008212","name":"College of Medicine, Drexel University","doi-asserted-by":"publisher","award":["MH092177"],"award-info":[{"award-number":["MH092177"]}],"id":[{"id":"10.13039\/100008212","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008212","name":"College of Medicine, Drexel University","doi-asserted-by":"publisher","award":["DA19807"],"award-info":[{"award-number":["DA19807"]}],"id":[{"id":"10.13039\/100008212","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008212","name":"College of Medicine, Drexel University","doi-asserted-by":"publisher","award":["NS46263"],"award-info":[{"award-number":["NS46263"]}],"id":[{"id":"10.13039\/100008212","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008212","name":"College of Medicine, Drexel University","doi-asserted-by":"publisher","award":["NS32092"],"award-info":[{"award-number":["NS32092"]}],"id":[{"id":"10.13039\/100008212","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008212","name":"College of Medicine, Drexel University","doi-asserted-by":"publisher","award":["NS089435"],"award-info":[{"award-number":["NS089435"]}],"id":[{"id":"10.13039\/100008212","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ruth L. Kirschstein National Research Service","award":["T32 MH079785"],"award-info":[{"award-number":["T32 MH079785"]}]},{"name":"Ruth L. Kirschstein National Research Service","award":["MH092177"],"award-info":[{"award-number":["MH092177"]}]},{"name":"Ruth L. Kirschstein National Research Service","award":["DA19807"],"award-info":[{"award-number":["DA19807"]}]},{"name":"Ruth L. Kirschstein National Research Service","award":["NS46263"],"award-info":[{"award-number":["NS46263"]}]},{"name":"Ruth L. Kirschstein National Research Service","award":["NS32092"],"award-info":[{"award-number":["NS32092"]}]},{"name":"Ruth L. Kirschstein National Research Service","award":["NS089435"],"award-info":[{"award-number":["NS089435"]}]},{"name":"Comprehensive NeuroAIDS Core Center","award":["T32 MH079785"],"award-info":[{"award-number":["T32 MH079785"]}]},{"name":"Comprehensive NeuroAIDS Core Center","award":["MH092177"],"award-info":[{"award-number":["MH092177"]}]},{"name":"Comprehensive NeuroAIDS Core Center","award":["DA19807"],"award-info":[{"award-number":["DA19807"]}]},{"name":"Comprehensive NeuroAIDS Core Center","award":["NS46263"],"award-info":[{"award-number":["NS46263"]}]},{"name":"Comprehensive NeuroAIDS Core Center","award":["NS32092"],"award-info":[{"award-number":["NS32092"]}]},{"name":"Comprehensive NeuroAIDS Core Center","award":["NS089435"],"award-info":[{"award-number":["NS089435"]}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["T32 MH079785"],"award-info":[{"award-number":["T32 MH079785"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["MH092177"],"award-info":[{"award-number":["MH092177"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["DA19807"],"award-info":[{"award-number":["DA19807"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["NS46263"],"award-info":[{"award-number":["NS46263"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["NS32092"],"award-info":[{"award-number":["NS32092"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["NS089435"],"award-info":[{"award-number":["NS089435"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute of Drug Abuse","doi-asserted-by":"crossref","award":["T32 MH079785"],"award-info":[{"award-number":["T32 MH079785"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000026","name":"National Institute of Drug Abuse","doi-asserted-by":"crossref","award":["MH092177"],"award-info":[{"award-number":["MH092177"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000026","name":"National Institute of Drug Abuse","doi-asserted-by":"crossref","award":["DA19807"],"award-info":[{"award-number":["DA19807"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000026","name":"National Institute of Drug Abuse","doi-asserted-by":"crossref","award":["NS46263"],"award-info":[{"award-number":["NS46263"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000026","name":"National Institute of Drug Abuse","doi-asserted-by":"crossref","award":["NS32092"],"award-info":[{"award-number":["NS32092"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000026","name":"National Institute of Drug Abuse","doi-asserted-by":"crossref","award":["NS089435"],"award-info":[{"award-number":["NS089435"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["T32 MH079785"],"award-info":[{"award-number":["T32 MH079785"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["MH092177"],"award-info":[{"award-number":["MH092177"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["DA19807"],"award-info":[{"award-number":["DA19807"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS46263"],"award-info":[{"award-number":["NS46263"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS32092"],"award-info":[{"award-number":["NS32092"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS089435"],"award-info":[{"award-number":["NS089435"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["T32 MH079785"],"award-info":[{"award-number":["T32 MH079785"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["MH092177"],"award-info":[{"award-number":["MH092177"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["DA19807"],"award-info":[{"award-number":["DA19807"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS46263"],"award-info":[{"award-number":["NS46263"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS32092"],"award-info":[{"award-number":["NS32092"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS089435"],"award-info":[{"award-number":["NS089435"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["T32 MH079785"],"award-info":[{"award-number":["T32 MH079785"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["MH092177"],"award-info":[{"award-number":["MH092177"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["DA19807"],"award-info":[{"award-number":["DA19807"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS46263"],"award-info":[{"award-number":["NS46263"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS32092"],"award-info":[{"award-number":["NS32092"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS089435"],"award-info":[{"award-number":["NS089435"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 MH079785"],"award-info":[{"award-number":["T32 MH079785"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["MH092177"],"award-info":[{"award-number":["MH092177"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DA19807"],"award-info":[{"award-number":["DA19807"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS46263"],"award-info":[{"award-number":["NS46263"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS32092"],"award-info":[{"award-number":["NS32092"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS089435"],"award-info":[{"award-number":["NS089435"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Genomics"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>Vpr is an HIV-1 accessory protein that plays numerous roles during viral replication, and some of which are cell type dependent. To test the hypothesis that HIV-1 tropism extends beyond the envelope into the<jats:italic>vpr<\/jats:italic>gene, studies were performed to identify the associations between coreceptor usage and Vpr variation in HIV-1-infected patients. Colinear HIV-1 Env-V3 and Vpr amino acid sequences were obtained from the LANL HIV-1 sequence database and from well-suppressed patients in the Drexel\/Temple Medicine CNS AIDS Research and Eradication Study (CARES) Cohort. Genotypic classification of Env-V3 sequences as X4 (CXCR4-utilizing) or R5 (CCR5-utilizing) was used to group colinear Vpr sequences. To reveal the sequences associated with a specific coreceptor usage genotype, Vpr amino acid sequences were assessed for amino acid diversity and Jensen-Shannon divergence between the two groups. Five amino acid alphabets were used to comprehensively examine the impact of amino acid substitutions involving side chains with similar physiochemical properties. Positions 36, 37, 41, 89, and 96 of Vpr were characterized by statistically significant divergence across multiple alphabets when X4 and R5 sequence groups were compared. In addition, consensus amino acid switches were found at positions 37 and 41 in comparisons of the R5 and X4 sequence populations. These results suggest an evolutionary link between Vpr and gp120 in HIV-1-infected patients.<\/jats:p>","DOI":"10.1155\/2017\/4081585","type":"journal-article","created":{"date-parts":[[2017,5,23]],"date-time":"2017-05-23T21:12:37Z","timestamp":1495573957000},"page":"1-11","source":"Crossref","is-referenced-by-count":5,"title":["Evidence of Divergent Amino Acid Usage in Comparative Analyses of R5- and X4-Associated HIV-1 Vpr Sequences"],"prefix":"10.1155","volume":"2017","author":[{"given":"Gregory C.","family":"Antell","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, USA"},{"name":"Center for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, PA, USA"},{"name":"School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3362-2610","authenticated-orcid":true,"given":"Will","family":"Dampier","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, USA"},{"name":"Center for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, PA, USA"},{"name":"School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0255-7203","authenticated-orcid":true,"given":"Benjamas","family":"Aiamkitsumrit","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, USA"},{"name":"Center for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4299-3779","authenticated-orcid":true,"given":"Michael R.","family":"Nonnemacher","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, USA"},{"name":"Center for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4922-8503","authenticated-orcid":true,"given":"Vanessa","family":"Pirrone","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, USA"},{"name":"Center for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, PA, USA"},{"name":"Center for Clinical and Translational Medicine, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, USA"},{"name":"Center for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Kercher","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, USA"},{"name":"Center for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shendra","family":"Passic","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, USA"},{"name":"Center for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, USA"},{"name":"Center for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yucheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, USA"},{"name":"Center for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony","family":"James","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, USA"},{"name":"Center for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey M.","family":"Jacobson","sequence":"additional","affiliation":[{"name":"Center for Clinical and Translational Medicine, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, PA, USA"},{"name":"Division of Infectious Diseases and HIV Medicine, Department of Medicine, Drexel University College of Medicine, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsofia","family":"Szep","sequence":"additional","affiliation":[{"name":"Center for Clinical and Translational Medicine, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, PA, USA"},{"name":"Division of Infectious Diseases and HIV Medicine, Department of Medicine, Drexel University College of Medicine, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5211-0936","authenticated-orcid":true,"given":"Brian","family":"Wigdahl","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, USA"},{"name":"Center for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, PA, USA"},{"name":"Center for Clinical and Translational Medicine, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, PA, USA"},{"name":"Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1530-4432","authenticated-orcid":true,"given":"Fred C.","family":"Krebs","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, USA"},{"name":"Center for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1007\/s11904-011-0107-3"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1038\/31405"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1186\/s12977-016-0266-9"},{"issue":"12, article a007443","key":"4","volume":"2","year":"2012","journal-title":"Cold Spring Harbor Perspectives in Medicine"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1038\/nri1527"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.2174\/1570162X12666140526121746"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1998.2381"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.1999.00858.x"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1033.2002.03067.x"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-8-25"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0107389"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004720"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1007\/s13365-014-0287-x"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a006965"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1097\/COH.0b013e328356f6f2"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1007\/s13365-010-0014-1"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000000163"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0150835"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.24.13376-13388.2003"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0107389"},{"issue":"3","key":"21","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1093\/protein\/13.3.149","volume":"13","year":"2000","journal-title":"Protein Engineering"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp163"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msr121"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1088\/1478-3975\/10\/3\/035005"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3950"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.2001.5293"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1110\/ps.03601504"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-11-92"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0155382"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1016\/S0753-3322(02)00328-1"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.7.3962-3972.2003"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.2174\/1568008043339668"},{"issue":"2","key":"33","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1128\/JVI.69.2.1243-1252.1995","volume":"69","year":"1995","journal-title":"Journal of Virology"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1038\/nm0198-065"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2014.00127"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1097\/01.aids.0000210611.60459.0e"},{"key":"37","first-page":"21","volume":"3","year":"1997","journal-title":"Progress in Cell Cycle Research"},{"issue":"51","key":"38","doi-asserted-by":"crossref","first-page":"32131","DOI":"10.1016\/S0021-9258(18)31610-7","volume":"269","year":"1994","journal-title":"The Journal of Biological Chemistry"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.2174\/157016211797635937"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1995.0079"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1172\/JCI16233"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1007\/s13365-016-0462-3"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2005.04.009"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1017\/S1462399405010239"},{"key":"45","first-page":"S24","volume":"6","year":"2000","journal-title":"Journal of Neurovirology"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.3109\/13550289909021293"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.4172\/2314-7326.S2-003"}],"container-title":["International Journal of Genomics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijg\/2017\/4081585.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijg\/2017\/4081585.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijg\/2017\/4081585.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T08:50:28Z","timestamp":1719219028000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/ijg\/2017\/4081585\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":47,"alternative-id":["4081585","4081585"],"URL":"https:\/\/doi.org\/10.1155\/2017\/4081585","relation":{},"ISSN":["2314-436X","2314-4378"],"issn-type":[{"value":"2314-436X","type":"print"},{"value":"2314-4378","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}