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This case\u2010control study analyzed the differences in the risk to develop CC between Chinese medicine (CM) users and nonusers among women who had ever been diagnosed as having cervical dysplasia. A total of 750 CC patients with a cervical dysplasia history were collected between 1998 and 2011 from National Health Insurance Research Database, and controls were women with cervical dysplasia history but did not develop CC. Adjusted odds ratio (aOR) for developing CC was assessed using multivariable logistic regression after adjusting for age, urbanization of residence, and occupation. The proportion of using CM among CC patients was lower than that among CC nonpatients, with an aOR of 0.8. By analyzing the relationship between CC development and the frequency of CM usage, the trend test revealed a significant decreasing trend for developing CC among high\u2010frequency CM users. Moreover, the most frequently used single herb high\u2010frequency was <jats:italic>Rheum palmatum<\/jats:italic> (Da\u2010Huang). The usage of CM might be an effective complementary method to prevent uterine cervix from progressing to CC after cervical dysplasia has occurred.<\/jats:p>","DOI":"10.1155\/2017\/4082630","type":"journal-article","created":{"date-parts":[[2017,12,31]],"date-time":"2017-12-31T23:31:58Z","timestamp":1514763118000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Use of Chinese Medicine Reduces the Development of Cervical Cancer from Pap Smear\u2010Diagnosed Cervical Dysplasia: A Case\u2010Control Study"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4376-7300","authenticated-orcid":false,"given":"Li-Ling","family":"Shen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih-Hsin","family":"Muo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0227-8471","authenticated-orcid":false,"given":"Shan-Yu","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald E.","family":"Morisky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,31]]},"reference":[{"volume-title":"Invasive cervical cancer: Epidemiology, risk factors, clinical manifestations, and diagnosis","year":"2015","author":"Frumovitz M.","key":"e_1_2_10_1_2"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.318.7188.904"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-14-505"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000000206"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004347-199304000-00018"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.52.6.342"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2003.07.008"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.12446"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0169363"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2005.03.031"},{"key":"e_1_2_10_11_2","article-title":"Anti-cancer effect of danshen and dihydroisotanshinone i on prostate cancer: Targeting the crosstalk between macrophages and cancer cells via inhibition of the stat3\/ccl2 signaling pathway","volume":"8","author":"Wu C. 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