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To emphasize the importance of a clinical suspicion of this dangerous condition, our experience with three difficult cases is presented. The diagnosis was based on clinical symptoms, otoscopic findings, and findings on computed tomography or magnetic resonance imaging. Neoplasm and granulomatous inflammation were excluded by multiple biopsies. The disease can develop in nondiabetic patients. The disorder might be related to the initial inflammatory process in the middle ear with further direct spreading of infection through defects in the bony walls to deep temporal bone structures. Imaging should be performed early to detect osteolytic lesions of the skull base. Surgery was used for the presence of bone sequestra and infratemporal abscess.<\/jats:p>","DOI":"10.1155\/2017\/4097973","type":"journal-article","created":{"date-parts":[[2017,4,9]],"date-time":"2017-04-09T21:00:39Z","timestamp":1491771639000},"page":"1-8","source":"Crossref","is-referenced-by-count":1,"title":["Clinical Challenges in the Diagnosis and Treatment of Temporal Bone Osteomyelitis"],"prefix":"10.1155","volume":"2017","author":[{"given":"Liubov","family":"Kornilenko","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Vilnius University, Ciurlionio 21\/27, LT-03101 Vilnius, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saulius","family":"Rocka","sequence":"additional","affiliation":[{"name":"Clinic of Neurology and Neurosurgery, Faculty of Medicine, Vilnius University, Siltnamiu 29, LT-04130 Vilnius, 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