{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:27:14Z","timestamp":1760027234014,"version":"3.37.3"},"reference-count":21,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Infectious Diseases"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>Meningitis in individuals living with acquired immunodeficiency syndrome (AIDS) is most frequently infectious in origin and usually due to opportunistic infections. The most common pathogens are<jats:italic> Cryptococcus neoformans<\/jats:italic> and<jats:italic> Mycobacterium tuberculosis<\/jats:italic>.<jats:italic> Treponema pallidum<\/jats:italic> causes neurosyphilis and can complicate HIV infections at any time after the initial infection. Simultaneous infections of the central nervous system caused by these pathogens are very uncommon even in the setting of severe immunosuppression. We report the case of a newly diagnosed HIV\/AIDS young man who was found to have neurosyphilis with<jats:italic> Cryptococcus<\/jats:italic> meningitis. After a few weeks of treatment and initiation of antiretroviral therapy, he was also diagnosed with tuberculous meningitis, which was probably unmasked by the development of immune reconstitution inflammatory syndrome (IRIS). To the best of our knowledge, this is the only case of reported neurosyphilis and meningitis caused concomitantly by<jats:italic> Cryptococcus<\/jats:italic> and<jats:italic> Mycobacterium tuberculosis.<\/jats:italic><\/jats:p>","DOI":"10.1155\/2017\/4103858","type":"journal-article","created":{"date-parts":[[2017,8,27]],"date-time":"2017-08-27T17:01:45Z","timestamp":1503853305000},"page":"1-5","source":"Crossref","is-referenced-by-count":5,"title":["Neurosyphilis with Concomitant Cryptococcal and Tuberculous Meningitis in a Patient with AIDS: Report of a Unique Case"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2768-9712","authenticated-orcid":true,"given":"Jose Armando","family":"Gonzales Zamora","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, University of Miami, Miller School of Medicine, Miami, FL 33136, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis Alberto","family":"Espinoza","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, University of Miami, Miller School of Medicine, Miami, FL 33136, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita N.","family":"Nwanyanwu","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, University of Miami, Miller School of Medicine, Miami, FL 33136, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1097\/qad.0b013e3282a4a64d"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/0303-8467(92)90014-T"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1071\/SH14195"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1056\/nejm198706183162503"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1086\/381227"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.51.4.1213"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.4103\/2249-4863.197304"},{"issue":"6","key":"8","first-page":"463","volume":"4","year":"2002","journal-title":"Israel Medical Association Journal"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/23.2.369"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1007\/s40475-015-0046-y"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.4172\/2155-6113.S3-003"},{"issue":"11","key":"12","first-page":"1555","volume":"17","year":"2013","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1177\/0956462414563630"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-197604000-00021"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1001\/jama.241.3.264"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00840-15"},{"issue":"4","key":"17","first-page":"588","volume":"16","year":"1993","journal-title":"Clinical Infectious Diseases"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nop053"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-8-190"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-13-600"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1086\/313685"}],"container-title":["Case Reports in Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/criid\/2017\/4103858.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/criid\/2017\/4103858.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/criid\/2017\/4103858.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,8,27]],"date-time":"2017-08-27T17:01:45Z","timestamp":1503853305000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/criid\/2017\/4103858\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":21,"alternative-id":["4103858","4103858"],"URL":"https:\/\/doi.org\/10.1155\/2017\/4103858","relation":{},"ISSN":["2090-6625","2090-6633"],"issn-type":[{"type":"print","value":"2090-6625"},{"type":"electronic","value":"2090-6633"}],"subject":[],"published":{"date-parts":[[2017]]}}}