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Prior studies suggest that renin-angiotensin-aldosterone system (RAAS) inhibitors decrease parathyroid hormone (PTH) secretion. <jats:italic>Objective<\/jats:italic>. To evaluate the effect of angiotensin-converting enzyme inhibitors (ACEi) on serum PTH in participants with and without primary hyperparathyroidism (P-HPT). <jats:italic>Methods<\/jats:italic>. An open-label, single-arm, pilot study whereby participants with and without P-HPT had PTH were evaluated before and after 1 week of maximally tolerated lisinopril therapy. <jats:italic>Results<\/jats:italic>. A total of 12 participants with, and 15 participants without, P-HPT successfully completed the protocol. Following 1 week of lisinopril, participants with P-HPT had a decrease in systolic blood pressure (SBP) (\u22126.4\u2009mmHg, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:math>), an increase in plasma renin activity (PRA) (+1.50\u2009ng\/mL\/h, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.06<\/mml:mn><\/mml:math>), and a decrease in PTH (79.5 (21.6) to 70.9 (19.6) pg\/mL, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mo>\u2206<\/mml:mo><mml:mo>=<\/mml:mo><mml:mo>\u2212<\/mml:mo><mml:mn>8.6<\/mml:mn><\/mml:math>\u2009pg\/mL, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.049<\/mml:mn><\/mml:math>); however, serum and urine calcium did not change. In contrast, although 1 week of lisinopril significantly decreased SBP and increased PRA among participants without P-HPT, there were no changes in PTH or calcium. <jats:italic>Conclusion<\/jats:italic>. In this short pilot investigation, 1 week of maximally titrated ACEi did not impact PTH in participants without P-HPT, but resulted in a modest and marginally significant reduction of PTH but not calcium, among participants with P-HPT. This trial is registered with ClinicalTrials.gov <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT01691781\">NCT01691781<\/jats:ext-link>.<\/jats:p>","DOI":"10.1155\/2017\/4138783","type":"journal-article","created":{"date-parts":[[2017,7,20]],"date-time":"2017-07-20T17:02:22Z","timestamp":1500570142000},"page":"1-8","source":"Crossref","is-referenced-by-count":11,"title":["Angiotensin-Converting Enzyme Inhibition and Parathyroid Hormone Secretion"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0621-5016","authenticated-orcid":true,"given":"Sarah","family":"Zaheer","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenifer 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