{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:52:23Z","timestamp":1790797943324,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computational and Mathematical Methods in Medicine"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>We evaluated the changes in the dose distribution of radiation during volumetric arc radiotherapy (VMAT), to determine the right time for adaptive replanning in prostate cancer patients with progressive weight (WT) changes. Five prostate cancer patients treated with VMAT were selected for dosimetric analysis. On the original computed tomography images, nine artificial body contours were created to reflect progressive WT changes. Combined with three different photon energies (6, 10, and 15-MV), 27 comparable virtual VMAT plans were created per patient. The dosimetric analysis included evaluation of target coverage <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mo stretchy=\"false\">(<\/mml:mo><mml:msub><mml:mrow><mml:mi>D<\/mml:mi><\/mml:mrow><mml:mrow><mml:mn fontstyle=\"italic\">95<\/mml:mn><mml:mi>%<\/mml:mi><\/mml:mrow><\/mml:msub><mml:mo>,<\/mml:mo><mml:msub><mml:mrow><mml:mi>D<\/mml:mi><\/mml:mrow><mml:mrow><mml:mtext>max<\/mml:mtext><\/mml:mrow><\/mml:msub><mml:mo stretchy=\"false\">)<\/mml:mo><\/mml:math>, conformity index, homogeneity index, and organs at risk doses. The dose differences among the plans were determined using the gamma index analysis and were compared with the dosimetric analysis. Mean <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:msub><mml:mrow><mml:mi>D<\/mml:mi><\/mml:mrow><mml:mrow><mml:mn fontstyle=\"italic\">95<\/mml:mn><mml:mi>%<\/mml:mi><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math> became lower than 98% when body contour expanded by 2.0\u2009cm or more and <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:msub><mml:mrow><mml:mi>D<\/mml:mi><\/mml:mrow><mml:mrow><mml:mtext>max<\/mml:mtext><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math> became higher than 107% when body contour contracted by 1.5\u2009cm or more in 10-MV plans. This cut-off values correlated well with gamma index analysis results. Adaptive replanning should, therefore, be considered if the depth of body contour becomes 1.5\u2009cm smaller (WT loss) or 2.0\u2009cm larger (WT gain) in patients treated by VMAT with 10-MV photons.<\/jats:p>","DOI":"10.1155\/2017\/4149591","type":"journal-article","created":{"date-parts":[[2017,12,18]],"date-time":"2017-12-18T18:34:33Z","timestamp":1513622073000},"page":"1-8","source":"Crossref","is-referenced-by-count":9,"title":["Defining the Optimal Time of Adaptive Replanning in Prostate Cancer Patients with Weight Change during Volumetric Arc Radiotherapy: A Dosimetric and Mathematical Analysis Using the Gamma Index"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0998-0685","authenticated-orcid":true,"given":"Hoon Sik","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Gyeongsang National University School of Medicine and Gyeongsang National University Changwon Hospital, Changwon 51472, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1987-7593","authenticated-orcid":true,"given":"Guang Sub","family":"Jo","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Gyeongsang National University School of Medicine and Gyeongsang National University Changwon Hospital, Changwon 51472, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7278-3062","authenticated-orcid":true,"given":"Jong Pyo","family":"Chae","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Gyeongsang National University School of Medicine and Gyeongsang National University Changwon Hospital, Changwon 51472, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4068-0704","authenticated-orcid":true,"given":"Sang 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