{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:29:42Z","timestamp":1790616582096,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Jiangsu Province Key Scientific and Technological Project","award":["BE2016669"],"award-info":[{"award-number":["BE2016669"]}]},{"name":"Jiangsu Province Key Scientific and Technological Project","award":["81120108003"],"award-info":[{"award-number":["81120108003"]}]},{"name":"Jiangsu Province Key Scientific and Technological Project","award":["81330007"],"award-info":[{"award-number":["81330007"]}]},{"name":"Jiangsu Province Key Scientific and Technological Project","award":["SS201665"],"award-info":[{"award-number":["SS201665"]}]},{"name":"Jiangsu Province Key Scientific and Technological Project","award":["XK201118"],"award-info":[{"award-number":["XK201118"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["BE2016669"],"award-info":[{"award-number":["BE2016669"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81120108003"],"award-info":[{"award-number":["81120108003"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81330007"],"award-info":[{"award-number":["81330007"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["SS201665"],"award-info":[{"award-number":["SS201665"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["XK201118"],"award-info":[{"award-number":["XK201118"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["BE2016669"],"award-info":[{"award-number":["BE2016669"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81120108003"],"award-info":[{"award-number":["81120108003"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81330007"],"award-info":[{"award-number":["81330007"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["SS201665"],"award-info":[{"award-number":["SS201665"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["XK201118"],"award-info":[{"award-number":["XK201118"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Suzhou Science and Technology Project","award":["BE2016669"],"award-info":[{"award-number":["BE2016669"]}]},{"name":"Suzhou Science and Technology Project","award":["81120108003"],"award-info":[{"award-number":["81120108003"]}]},{"name":"Suzhou Science and Technology Project","award":["81330007"],"award-info":[{"award-number":["81330007"]}]},{"name":"Suzhou Science and Technology Project","award":["SS201665"],"award-info":[{"award-number":["SS201665"]}]},{"name":"Suzhou Science and Technology Project","award":["XK201118"],"award-info":[{"award-number":["XK201118"]}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"crossref","award":["BE2016669"],"award-info":[{"award-number":["BE2016669"]}],"id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"crossref","award":["81120108003"],"award-info":[{"award-number":["81120108003"]}],"id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"crossref","award":["81330007"],"award-info":[{"award-number":["81330007"]}],"id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"crossref","award":["SS201665"],"award-info":[{"award-number":["SS201665"]}],"id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"crossref","award":["XK201118"],"award-info":[{"award-number":["XK201118"]}],"id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Jiangsu Province\u2019s Key Discipline\/Laboratory of Medicine","award":["BE2016669"],"award-info":[{"award-number":["BE2016669"]}]},{"name":"Jiangsu Province\u2019s Key Discipline\/Laboratory of Medicine","award":["81120108003"],"award-info":[{"award-number":["81120108003"]}]},{"name":"Jiangsu Province\u2019s Key Discipline\/Laboratory of Medicine","award":["81330007"],"award-info":[{"award-number":["81330007"]}]},{"name":"Jiangsu Province\u2019s Key Discipline\/Laboratory of Medicine","award":["SS201665"],"award-info":[{"award-number":["SS201665"]}]},{"name":"Jiangsu Province\u2019s Key Discipline\/Laboratory of Medicine","award":["XK201118"],"award-info":[{"award-number":["XK201118"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>Mesenchymal stem cells (MSCs) repair infarcted heart through paracrine mechanism. We sought to compare the effectiveness of MSCs and MSC-derived exosomes (MSC-Exo) in repairing infarcted hearts and to identify how MSC-Exo mediated cardiac repair is regulated. In a rat myocardial infarction model, we found that MSC-Exo inhibited cardiac fibrosis, inflammation, and improved cardiac function. The beneficial effects of MSC-Exo were significantly superior compared to that of MSCs. To explore the potential mechanisms underlying MSC-Exo\u2019s effects, we performed several in vitro experiments and miRNA-sequence analysis. MSC-Exo stimulated cardiomyocyte H9C2 cell proliferation, inhibited apoptosis induced by H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>, and inhibited TGF-<jats:italic>\u03b2<\/jats:italic> induced transformation of fibroblast cell into myofibroblast. Importantly, novel miRNA sequencing results indicated that MSC-Exo and MSCs have similar miRNA expression profile, which could be one of the reasons that MSC-Exo can replace MSCs for cardiac repair. In addition, the expression of several miRNAs from MSC-Exo was significantly different from that of MSCs, which may explain why MSC-Exo has better therapeutic effect than MSCs. In conclusion, this study demonstrates that MSC-Exo could be used alone to promote cardiac repair and are superior to MSCs in repairing injured myocardium.<\/jats:p>","DOI":"10.1155\/2017\/4150705","type":"journal-article","created":{"date-parts":[[2017,1,22]],"date-time":"2017-01-22T21:01:32Z","timestamp":1485118892000},"page":"1-9","source":"Crossref","is-referenced-by-count":243,"title":["MiRNA-Sequence Indicates That Mesenchymal Stem Cells and Exosomes Have Similar Mechanism to Enhance Cardiac Repair"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9322-9581","authenticated-orcid":true,"given":"Lianbo","family":"Shao","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery, The First Affiliated Hospital and The Institute for Cardiovascular Science, Soochow University, Suzhou, Jiangsu 215123, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, The First Affiliated Hospital and The Institute for Cardiovascular Science, Soochow University, Suzhou, Jiangsu 215123, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beibei","family":"Lan","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, The First Affiliated Hospital and The Institute for Cardiovascular Science, Soochow University, Suzhou, Jiangsu 215123, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juanjuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, The First Affiliated Hospital and The Institute for Cardiovascular Science, Soochow University, Suzhou, Jiangsu 215123, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, The First Affiliated Hospital and The Institute for Cardiovascular Science, Soochow University, Suzhou, Jiangsu 215123, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lulu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, The First Affiliated Hospital and The Institute for Cardiovascular Science, Soochow University, Suzhou, Jiangsu 215123, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengli","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, The First Affiliated Hospital and The Institute for Cardiovascular Science, Soochow University, Suzhou, Jiangsu 215123, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyou","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, The First Affiliated Hospital and The Institute for Cardiovascular Science, Soochow University, Suzhou, Jiangsu 215123, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-jian","family":"Geng","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Texas, Houston, TX 77583, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi-yong","family":"Yu","sequence":"additional","affiliation":[{"name":"Guangzhou Medical University, Guangzhou, Guangdong 510080, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2364-3207","authenticated-orcid":true,"given":"Yangxin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, The First Affiliated Hospital and The Institute for Cardiovascular Science, Soochow University, Suzhou, Jiangsu 215123, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000225952.61196.39"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0042964"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-10-115"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.06.055"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.25321"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.113.300219"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.7727"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2014.207"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2014.207-c1"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/482171"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-015-0116"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M003657"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1038\/nri2567"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1159\/000438594"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035685"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2009.12.003"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-013-1110-5"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0090667"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2008.10.021"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2005.04.007"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2011.01.014"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.222703"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-04-1488"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.852285"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1546"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1096\/fj.09-143180"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1080\/14653240801950000"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.3109\/08977194.2011.595714"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1161\/jaha.115.002856"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.111.253286"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.113.007917"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2011010055"},{"key":"33","volume":"5, article 5214","year":"2014","journal-title":"Nature Communications"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20101547"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1038\/nature11919"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1206432109"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2012.10.060"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.000882"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1172\/JCI70577"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.244442"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2017\/4150705.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2017\/4150705.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2017\/4150705.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T14:07:28Z","timestamp":1589724448000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/bmri\/2017\/4150705\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":40,"alternative-id":["4150705","4150705"],"URL":"https:\/\/doi.org\/10.1155\/2017\/4150705","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}