{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T19:08:55Z","timestamp":1740164935832,"version":"3.37.3"},"reference-count":6,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Surgery"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p><jats:italic>Introduction.<\/jats:italic> It is rare for actinic or squamous cell carcinoma (SCC) in situ to metastasize.<jats:italic> Case Presentation.<\/jats:italic> A 67-year-old male had a significant medical history including severe psoriatic arthritis treated with UVB, methotrexate, and rapamycin. He had twenty-five different skin excisions of actinic keratosis four of which were invasive SCC. Our patient developed shortness of breath necessitating a visit to the emergency department. A CT scan of his chest revealed a mass in the right lower lung. A subsequent biopsy of the mass revealed well-differentiated SCC. He underwent thoracoscopic surgery with wedge resection of the lung lesion.<jats:italic> Discussion.<\/jats:italic> Actinic keratosis (AK) is considered precancerous and associated with UV exposure. It exists as a continuum of progression with low potential for malignancy. The majority of invasive SCCs are associated with malignant progression of AK, but only 5\u201310% of AKs will progress to malignant potential.<jats:italic> Conclusion.<\/jats:italic> In this case, a new finding of lung SCC in the setting of multiple invasive actinic cutaneous SCC associated with a history of extensive UV light exposure and immunosuppression supports a metastatic explanation for lung cancer.<\/jats:p>","DOI":"10.1155\/2017\/4176071","type":"journal-article","created":{"date-parts":[[2017,3,13]],"date-time":"2017-03-13T17:25:26Z","timestamp":1489425926000},"page":"1-4","source":"Crossref","is-referenced-by-count":1,"title":["Suspected Pulmonary Metastasis of Actinic Cutaneous Squamous Cell Carcinoma"],"prefix":"10.1155","volume":"2017","author":[{"given":"Monet E.","family":"Meter","sequence":"first","affiliation":[{"name":"Department of Medicine, Sky Ridge Medical Center, Lone Tree, CO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0153-8289","authenticated-orcid":true,"given":"David J.","family":"Nye","sequence":"additional","affiliation":[{"name":"Department of Surgery, Berkshire Medical Center, Pittsfield, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian R.","family":"Galvez","sequence":"additional","affiliation":[{"name":"Department of Surgery, Berkshire Medical Center, Pittsfield, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7819-9-80"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/210813"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2009.03.063"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2006.10.017"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1097\/PAI.0b013e3181ecaf1c"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.317"}],"container-title":["Case Reports in Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cris\/2017\/4176071.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cris\/2017\/4176071.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cris\/2017\/4176071.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,3,13]],"date-time":"2017-03-13T17:25:26Z","timestamp":1489425926000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/cris\/2017\/4176071\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":6,"alternative-id":["4176071","4176071"],"URL":"https:\/\/doi.org\/10.1155\/2017\/4176071","relation":{},"ISSN":["2090-6900","2090-6919"],"issn-type":[{"type":"print","value":"2090-6900"},{"type":"electronic","value":"2090-6919"}],"subject":[],"published":{"date-parts":[[2017]]}}}