{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T21:03:06Z","timestamp":1740171786641,"version":"3.37.3"},"reference-count":44,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81270289","81300170"],"award-info":[{"award-number":["81270289","81300170"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81270289","81300170"],"award-info":[{"award-number":["81270289","81300170"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>To explore the role of<jats:italic>Interkeulin-31 (IL-31)<\/jats:italic>in dilated cardiomyopathy (DCM), in our study, two SNPs of<jats:italic>IL-31<\/jats:italic>, rs4758680 (C\/A) and rs7977932 (C\/G), were analyzed in 331 DCM patients and 493 controls in a Chinese Han population. The frequencies of C allele and CC genotype of rs4758680 were significantly increased in DCM patients (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.005<\/mml:mn><\/mml:math>,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>, resp.). Compared to CC genotype of rs4758680, the A carriers (CA\/AA genotypes) were the protect factors in DCM susceptibility while the frequencies of CA\/AA genotypes were decreased in the dominant model for DCM group (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>, OR\u2009=\u20090.56, 95%CI\u2009=\u20090.39\u20130.79). Moreover, IL-31 mRNA expression level of white blood cells was increased in DCM patients (0.072 (0.044\u20130.144) versus 0.036 (0.020\u20130.052),<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>). In survival analysis of 159 DCM patients, Kaplan-Meier curve revealed the correlation between CC homozygote of rs4758680 and worse prognosis for DCM group (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.005<\/mml:mn><\/mml:math>). Compared to CC genotype, the CA\/AA genotypes were the independent factors in both univariate (HR\u2009=\u20090.530, 95%CI\u2009=\u20090.337\u20130.834,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.006<\/mml:mn><\/mml:math>) and multivariate analyses after age, gender, left ventricular end-diastolic diameter, and left ventricular ejection fraction adjusted (HR\u2009=\u20090.548, 95%CI\u2009=\u20090.345\u20130.869,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.011<\/mml:mn><\/mml:math>). Thus, we concluded that<jats:italic>IL-31<\/jats:italic>gene polymorphisms were tightly associated with DCM susceptibility and contributed to worse prognosis in DCM patients.<\/jats:p>","DOI":"10.1155\/2017\/4191365","type":"journal-article","created":{"date-parts":[[2017,5,11]],"date-time":"2017-05-11T12:51:27Z","timestamp":1494507087000},"page":"1-10","source":"Crossref","is-referenced-by-count":6,"title":["Associations between<i>Interleukin-31<\/i>Gene Polymorphisms and Dilated Cardiomyopathy in a Chinese Population"],"prefix":"10.1155","volume":"2017","author":[{"given":"Huizi","family":"Song","sequence":"first","affiliation":[{"name":"Department of Cardiology, West China Hospital of Sichuan University, Chengdu 610041, China"},{"name":"West China School of Medicine\/West China Hospital of Sichuan University, Chengdu 610041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of 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