{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T03:23:47Z","timestamp":1762917827067,"version":"3.37.3"},"reference-count":32,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>Here we investigated CD44 protein expression and its polymorphisms in patients with chronic gastritis, precancerous gastric lesions, and gastric cancer; and we evaluated our result with the risk of CD44 protein expression and clinicopathological characteristics. Our results obtained by analyzing 162 gastric cancer patients, 125 chronic gastritis, and 165 precancerous gastric lesions from three study centers in Thailand showed that CD44 expression was significantly higher in patients with precancerous gastric lesions and gastric cancer while patients with chronic gastritis were negative for CD44 staining (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.036<\/mml:mn><\/mml:math>). We further observed the significant association of variant genotype; gastric cancer patients carrying AG or GG of CD44 rs187116 had more increased risk of CD44 expression than wild-type (WT) carriers (AG: odds ratio (OR) = 5.67; 95% CI = 1.57\u20137.23; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0<\/mml:mn><mml:mo>.<\/mml:mo><mml:mn fontstyle=\"italic\">024<\/mml:mn><\/mml:math> and GG: OR = 8.32; 95% CI = 2.94\u201311.42; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0<\/mml:mn><mml:mo>.<\/mml:mo><mml:mn fontstyle=\"italic\">016<\/mml:mn><\/mml:math>), but no significant difference in the risk of CD44 expression due to polymorphism in patients with precancerous gastric lesions. Our results suggested that CD44 expression could be used as a marker for the prediction of gastric cancer development, particularly in patients with precancerous gastric lesions carrying AG or GG, who were selected to surveillance follow-up for gastric cancer prevention.<\/jats:p>","DOI":"10.1155\/2017\/4384823","type":"journal-article","created":{"date-parts":[[2017,12,27]],"date-time":"2017-12-27T18:31:41Z","timestamp":1514399501000},"page":"1-8","source":"Crossref","is-referenced-by-count":16,"title":["Expression of Cancer Stem Cell Marker CD44 and Its Polymorphisms in Patients with Chronic Gastritis, Precancerous Gastric Lesion, and Gastric Cancer: A Cross-Sectional Multicenter Study in Thailand"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1976-9878","authenticated-orcid":true,"given":"Taweesak","family":"Tongtawee","sequence":"first","affiliation":[{"name":"School of Surgery, Institute of Medicine, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand"},{"name":"Suranaree University of Technology Hospital, Nakhon Ratchasima 30000, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wareeporn","family":"Wattanawongdon","sequence":"additional","affiliation":[{"name":"School of Surgery, Institute of Medicine, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theeraya","family":"Simawaranon","sequence":"additional","affiliation":[{"name":"School of Surgery, Institute of Medicine, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soraya","family":"Kaewpitoon","sequence":"additional","affiliation":[{"name":"School of Family Medicine, Institute of Medicine, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sivamate","family":"Kaengpenkae","sequence":"additional","affiliation":[{"name":"Department of Surgery, Surin Hospital, Surin 32000, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nichaphat","family":"Jintabanditwong","sequence":"additional","affiliation":[{"name":"Department of Surgery, Surin Hospital, Surin 32000, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pakorn","family":"Tangjanyatham","sequence":"additional","affiliation":[{"name":"Buriram Hospital, Buriram 31000, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Warisara","family":"Ratchapol","sequence":"additional","affiliation":[{"name":"Buriram Hospital, Buriram 31000, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kokiet","family":"Kangwantas","sequence":"additional","affiliation":[{"name":"School of Oncology, Institute of Medicine, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chavaboon","family":"Dechsukhum","sequence":"additional","affiliation":[{"name":"School of Pathology, Institute of Medicine, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2758-9276","authenticated-orcid":true,"given":"Wilairat","family":"Leeanansaksiri","sequence":"additional","affiliation":[{"name":"School of Preclinic, Institute of Science, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natthawut","family":"Kaewpitoon","sequence":"additional","affiliation":[{"name":"Faculty of Public Health, Vongchavalitkul University, Nakhon Ratchasima 30000, 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