{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:40:29Z","timestamp":1789000829490,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Canadian Journal of Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    . A new agent, potassium-competitive acid blocker vonoprazan (VPZ) has potent acid-inhibitory effects and may offer advantages over conventional\n                    <jats:italic>H. pylori<\/jats:italic>\n                    eradication therapies. We aimed to compare the eradication rate between VPZ-based treatment and PPI-based one.\n                    <jats:italic>Methods<\/jats:italic>\n                    . This randomized controlled trial was designed to assign 141 patients with\n                    <jats:italic>H. pylori-<\/jats:italic>\n                    positive gastritis to VPZ group (VPZ 20 mg, amoxicillin 750 mg, and clarithromycin 200 or 400 mg twice daily for 7 days) or PPI group (rabeprazole 20 mg or lansoprazole 30 mg, amoxicillin 750 mg, and clarithromycin 200 or 400 mg twice daily for 7 days). Primary endpoints were eradication rates and adverse events.\n                    <jats:italic>Results<\/jats:italic>\n                    . Seventy of 72 patients in VPZ group and 63 of 69 patients in PPI group completed the treatment after 7 days. The eradication rate was significantly higher in VPZ group than PPI group by intention-to-treat analysis (95.8% versus 69.6%,\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                      <mml:mi>P<\/mml:mi>\n                      <mml:mo>=<\/mml:mo>\n                      <mml:mn fontstyle=\"italic\">0.0000<\/mml:mn>\n                      <mml:mn fontstyle=\"italic\">3<\/mml:mn>\n                    <\/mml:math>\n                    , 95% confidence interval [CI] 88.3-99.1% versus 57.3-80.1%) and per-protocol analysis (95.7% versus 71.4%,\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                      <mml:mi>P<\/mml:mi>\n                      <mml:mo>=<\/mml:mo>\n                      <mml:mn fontstyle=\"italic\">0.0002<\/mml:mn>\n                    <\/mml:math>\n                    , 95% CI 88.0-99.1% versus 58.7-82.1%). The incidence of adverse events was not different between the groups (26.3% in VPZ group versus 37.7% in PPI group,\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                      <mml:mi>P<\/mml:mi>\n                      <mml:mo>=<\/mml:mo>\n                      <mml:mn fontstyle=\"italic\">0.15<\/mml:mn>\n                    <\/mml:math>\n                    ).\n                    <jats:italic>Conclusion<\/jats:italic>\n                    . VPZ-based regimen is more useful than that PPI-based regimen as a first-line\n                    <jats:italic>H. pylori<\/jats:italic>\n                    eradication therapy.\n                  <\/jats:p>","DOI":"10.1155\/2017\/4385161","type":"journal-article","created":{"date-parts":[[2017,2,28]],"date-time":"2017-02-28T19:53:47Z","timestamp":1488311627000},"page":"1-7","source":"Crossref","is-referenced-by-count":78,"title":["Vonoprazan-Based Regimen Is More Useful than PPI-Based One as a First-Line\n                    <i>Helicobacter pylori<\/i>\n                    Eradication: A Randomized Controlled Trial"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0381-200X","authenticated-orcid":true,"given":"Masafumi","family":"Maruyama","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Nagano Red Cross Hospital, Nagano, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Metabolic Regulation, Shinshu University Graduate School of Medicine, Matsumoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Kubota","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Nagano Red Cross Hospital, Nagano, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Miyajima","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Nagano Red Cross Hospital, Nagano, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1481-1029","authenticated-orcid":true,"given":"Takefumi","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Nagano Red Cross Hospital, Nagano, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koujiro","family":"Tokutake","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Nagano Red Cross Hospital, Nagano, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryujiro","family":"Imai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Nagano Red Cross Hospital, Nagano, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Fujisawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Nagano Red Cross Hospital, Nagano, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromitsu","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Nagano Red Cross Hospital, Nagano, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiaki","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Nagano Red Cross Hospital, Nagano, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuichi","family":"Wada","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Nagano Red Cross Hospital, Nagano, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Horiuchi","sequence":"additional","affiliation":[{"name":"Digestive Disease Center, Showa Inan General Hospital, Komagane, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kendo","family":"Kiyosawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Aizawa Hospital, Matsumoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","series-title":"IARC Monographs on the Evaluation of 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