{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T22:16:56Z","timestamp":1762899416253,"version":"3.37.3"},"reference-count":34,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"JSPS Grant-in-Aid for Young Scientists (B)","award":["26870605","17K18131"],"award-info":[{"award-number":["26870605","17K18131"]}]},{"name":"JSPS Grant-in-Aid for Young Scientists (B)","award":["26870605","17K18131"],"award-info":[{"award-number":["26870605","17K18131"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p><jats:italic>Objectives.<\/jats:italic> To evaluate 24-hour intraocular pressure (IOP) variation in patients with primary open-angle glaucoma (POAG) treated with triple eye drops. <jats:italic>Subjects and Methods.<\/jats:italic> The IOP was measured in 74 eyes in 74 POAG patients (seated) on triple therapy (PG analogue, <jats:italic>\u03b2<\/jats:italic>-blocker, carbonic anhydrase inhibitor) at about every 3 hours. <jats:italic>Results.<\/jats:italic> The peak IOP was 13.5\u2009\u00b1\u20093.1 at 1:00, and the trough IOP was at 12.6\u2009\u00b1\u20092.4\u2009mmHg at 7:00. The IOP at 7:00 was significantly lower than that at 10:00, 1:00, and 3:00 (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>). Based on the time of the peak IOP, we classified the patients into two groups: diurnal (28 eyes) and nocturnal types (37 eyes). There was significant difference at the spherical equivalent between diurnal and nocturnal types (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.014<\/mml:mn><\/mml:math>). To assess the influence of reflective error, we conducted subanalysis for two groups: high myopic (26 eyes, \u2264\u22126D) and low\/nonmyopic (24 eyes, \u2265\u22122D) groups. In the low\/nonmyopia group, the IOP was significantly higher at 1:00 and 3:00 than at 13:00, 16:00, and 7:\u200900 (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>). <jats:italic>Conclusion.<\/jats:italic> The mean of IOP elevated outside of clinic hour in the POAG patients on triple therapy. The low\/nonmyopia patient should be carefully treated because the IOP of the patients at night elevated significantly.<\/jats:p>","DOI":"10.1155\/2017\/4398494","type":"journal-article","created":{"date-parts":[[2017,5,3]],"date-time":"2017-05-03T17:00:35Z","timestamp":1493830835000},"page":"1-6","source":"Crossref","is-referenced-by-count":7,"title":["Twenty-Four-Hour Variation of Intraocular Pressure in Primary Open-Angle Glaucoma Treated with Triple Eye Drops"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3707-4893","authenticated-orcid":true,"given":"Yoshinori","family":"Itoh","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Jikei University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Nakamoto","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Tokyo Metropolitan Police Hospital, Tokyo, Japan"},{"name":"Department of 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Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Niizashiki Central General Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadashi","family":"Nakano","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Jikei University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4008-9014","authenticated-orcid":true,"given":"Hiroshi","family":"Tsuneoka","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Jikei University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriko","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Showa University School of Medicine, Tokyo, 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