{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:50:26Z","timestamp":1787017826448,"version":"build-2736575974"},"reference-count":16,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Critical Care"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>\n                    <jats:italic>Purpose<\/jats:italic>\n                    . To report a case series of three patients who developed significant bradycardia while receiving the combination of dexmedetomidine and fentanyl for sedation and analgesia.\n                    <jats:italic>Materials and Methods<\/jats:italic>\n                    . This is a case series of patients obtained from a mixed medical, surgical, and cardiac ICU in a community teaching hospital. Three intubated patients receiving fentanyl and dexmedetomidine infusion developed sudden bradycardia requiring intervention. In all three cases, adjustments to therapy were required.\n                    <jats:italic>Results<\/jats:italic>\n                    . All three patients experienced significant bradycardia, with a heart rate less than 50\u2009bpm, and one patient briefly developed asystole. In Case\u2009\u20091, the fentanyl infusion rate was reduced by 67% and the dexmedetomidine infusion rate was reduced by 25%. In Case\u2009\u20092, the sedation was changed to midazolam, and in Case\u2009\u20093, both fentanyl and dexmedetomidine were discontinued. In all three cases, there were no further incidences of significant bradycardia following intervention.\n                    <jats:italic>Conclusions<\/jats:italic>\n                    . Fentanyl used in combination with dexmedetomidine can result in clinically significant bradycardia. Further study is warranted to identify risk factors and elucidate the mechanisms that result in life-threatening bradycardia.\n                  <\/jats:p>","DOI":"10.1155\/2017\/4504207","type":"journal-article","created":{"date-parts":[[2017,9,6]],"date-time":"2017-09-06T17:55:45Z","timestamp":1504720545000},"page":"1-4","source":"Crossref","is-referenced-by-count":5,"title":["Significant Bradycardia in Critically Ill Patients Receiving Dexmedetomidine and Fentanyl"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5730-5652","authenticated-orcid":true,"given":"Channing","family":"Hui","sequence":"first","affiliation":[{"name":"Rutgers-Robert Wood Johnson Medical School, Department of Emergency Medicine, One Robert Wood Johnson Place, MEB 389, New Brunswick, NJ 08901, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Cardinale","sequence":"additional","affiliation":[{"name":"Ernest Mario School of Pharmacy, Rutgers University, 160 Frelinghuysen Rd., Piscataway Township, NJ 08854, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balaji","family":"Yegneswaran","sequence":"additional","affiliation":[{"name":"Saint Peter\u2019s University Hospital, 254 Easton Ave., New Brunswick, NJ 08901, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3182783b72"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2016.3274"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(88)90744-3"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.2165\/11207190-000000000-00000"},{"key":"5","volume":"14","year":"2001"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1P726"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200008000-00016"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000001125"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199902000-00034"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.1982.tb01772.x"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(02)00657-7"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2004.02.010"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1h423"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199404000-00017"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(87)90670-6"},{"key":"16","year":"2016"}],"container-title":["Case Reports in Critical Care"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cricc\/2017\/4504207.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cricc\/2017\/4504207.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cricc\/2017\/4504207.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,9,6]],"date-time":"2017-09-06T17:55:46Z","timestamp":1504720546000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/cricc\/2017\/4504207\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":16,"alternative-id":["4504207","4504207"],"URL":"https:\/\/doi.org\/10.1155\/2017\/4504207","relation":{},"ISSN":["2090-6420","2090-6439"],"issn-type":[{"value":"2090-6420","type":"print"},{"value":"2090-6439","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}