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Hyperventilation\u2010induced CO<jats:sub>2<\/jats:sub>reactivity of the middle cerebral artery was measured in 12 healthy male volunteers (mean age: 26.3 \u00b1 1.1 years) using transcranial Doppler sonography. All subjects were examined before and for 3 hours after administration, with an interval of 1 week between measurements.<jats:italic>Results<\/jats:italic>. Compared to baseline, the CO<jats:sub>2<\/jats:sub>reactivity of the middle cerebral artery increased significantly at 2 and 3 hours after the administration of CHD (600\u2009mg and 1200\u2009mg). The mean blood pressure and heart rate did not vary from the baseline values in all groups.<jats:italic>Conclusion<\/jats:italic>. These data suggest that CHD administration (especially 600\u2009mg) immediately improves cerebral blood flow.<\/jats:p>","DOI":"10.1155\/2017\/4567217","type":"journal-article","created":{"date-parts":[[2017,4,20]],"date-time":"2017-04-20T21:01:02Z","timestamp":1492722062000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Effect of Chunghyul\u2010Dan on Hyperventilation\u2010Induced Carbon Dioxide Reactivity of the Middle Cerebral Artery in Normal Subjects: A Dose\u2010Dependent Study"],"prefix":"10.1155","volume":"2017","author":[{"given":"Chul","family":"Jin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang-Kwan","family":"Moon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3149-9759","authenticated-orcid":false,"given":"Seung-Yeon","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8611-568X","authenticated-orcid":false,"given":"Seong-Uk","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woo-Sang","family":"Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung-Mi","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang-Nam","family":"Ko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ki-Ho","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1857-3515","authenticated-orcid":false,"given":"Seungwon","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,4,20]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.25.1442"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1142\/s0192415x05002898"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X06004090"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.27.1810"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/19768354.2010.525824"},{"key":"e_1_2_7_6_2","first-page":"21","article-title":"The protective effect of Chunghul-dan(Quingwuedan) against 6-hydroxydopamine induced neurotoxicity","volume":"20","author":"Kim G. 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