{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:46:11Z","timestamp":1760550371771,"version":"3.37.3"},"reference-count":59,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Metabolic Fitness Association"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. Quantitative ultrasound (QUS) provides an estimate of bone mineral density (BMD) and also evaluates bone quality, which has been related to increased fracture risk in people with diabetes. This study aimed at assessing the correlates of calcaneal QUS parameters in diabetic subjects encompassing various degrees of micro and macrovascular complications and a wide-range of peripheral nerve function. <jats:italic>Methods<\/jats:italic>. Four hundred consecutive diabetic patients were examined by QUS to obtain values of broadband ultrasound attenuation (BUA), the speed of sound (SOS), quantitative ultrasound index (QUI), and BMD. <jats:italic>Results<\/jats:italic>. Among surrogate measures of complications, sensory and motor nerve amplitude and heart rate response to cough test and standing correlated with QUS parameters at univariate analysis, together with age, body mass index (BMI), waist circumference, lipid profile, and renal function. Multivariate analysis revealed that BUA, SOS, QUI, and BMD were independently associated with age, male gender, hemoglobin A<jats:sub>1c<\/jats:sub>, BMI (or fat, but not fat-free mass), and somatic and autonomic nerve function parameters. <jats:italic>Conclusions<\/jats:italic>. These data indicate that peripheral nerve dysfunction is associated with worse QUS parameters, possibly contributing to increased fracture risk in diabetes. The positive relation of QUS measures with adiposity needs further investigation. This trial is registered with ClinicalTrials.gov (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT01600924\">NCT01600924<\/jats:ext-link>).<\/jats:p>","DOI":"10.1155\/2017\/4749619","type":"journal-article","created":{"date-parts":[[2017,9,19]],"date-time":"2017-09-19T17:03:04Z","timestamp":1505840584000},"page":"1-12","source":"Crossref","is-referenced-by-count":10,"title":["Correlates of Calcaneal Quantitative Ultrasound Parameters in Patients with Diabetes: The Study on the Assessment of Determinants of Muscle and Bone Strength Abnormalities in Diabetes"],"prefix":"10.1155","volume":"2017","author":[{"given":"Francesco","family":"Conti","sequence":"first","affiliation":[{"name":"Department of Clinical and Molecular Medicine, \u201cLa Sapienza\u201d University, Via di Grottarossa 1035, 00189 Rome, Italy"},{"name":"Diabetes Unit, Sant\u2019Andrea Hospital, Via di Grottarossa 1035, 00189 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