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Diffusion tensor imaging (DTI) and DKI during 7.0\u2009T MRI were performed in the frontal lobe and thalamus before and 30\u2009min, 2\u2009h, and 6\u2009h after ethyl alcohol administration. Compared with controls, mean kurtosis values of the frontal lobe and thalamus first decreased by 44% and 38% within 30\u2009min (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.01<\/mml:mn><\/mml:math> all) and then increased by 14% and 46% at 2\u2009h (frontal lobe, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>&gt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.05<\/mml:mn><\/mml:math>; thalamus, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.01<\/mml:mn><\/mml:math>) and by 29% and 68% at 6\u2009h (frontal lobe, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.05<\/mml:mn><\/mml:math>; thalamus, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.01<\/mml:mn><\/mml:math>) after acute intake. Mean diffusivity decreased significantly in both the frontal lobe and the thalamus at various stages. However, fractional anisotropy decreased only in the frontal lobe, with no detectable change in the thalamus. This demonstrates that DKI possesses sufficient sensitivity for tracking pathophysiological changes at various stages associated with acute alcohol intoxication and may provide additional information that may be missed by conventional DTI parameters.<\/jats:p>","DOI":"10.1155\/2017\/4757025","type":"journal-article","created":{"date-parts":[[2017,1,18]],"date-time":"2017-01-18T16:09:04Z","timestamp":1484755744000},"page":"1-6","source":"Crossref","is-referenced-by-count":4,"title":["Diffusion Kurtosis Imaging Detects Microstructural Changes in the Brain after Acute Alcohol Intoxication in Rats"],"prefix":"10.1155","volume":"2017","author":[{"given":"Xi-ran","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Radiology, The Second Affiliated Hospital, Shantou University Medical College, Shantou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie-ying","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of 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