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Tumor necrosis factor-<jats:italic>\u03b1<\/jats:italic>-induced protein 8-like 2 (TIPE2 or TNFAIP8L2) is a negative regulator of natural and adaptive immunity. The role of TIPE2 in type 2 diabetes mellitus (T2DM) remains unknown, although TIPE2 plays key roles in preserving inflammatory homeostasis. <jats:italic>Methods<\/jats:italic>. TIPE2 expression was measured by Western blotting and real-time polymerase chain reaction (RT-PCR) in peripheral blood mononuclear cells (PBMCs) isolated from T2DM patients and healthy controls, and tumor necrosis factor-<jats:italic>\u03b1<\/jats:italic> (TNF-<jats:italic>\u03b1<\/jats:italic>), high-sensitivity C-reactive protein (hsCRP), interleukin 6 (IL-6), and other related biometabolic parameters were detected using a nephelometer or by ELISA. Differentiated THP-1 cells were exposed to siTIPE2 and TIPE2 adenovirus. <jats:italic>Results<\/jats:italic>. TIPE2 was significantly increased in PBMCs from T2DM patients compared with those from healthy controls and was negatively correlated with serum TNF-<jats:italic>\u03b1<\/jats:italic>, IL-6, and hsCRP concentrations but positively correlated with HbA1c and LDL-C in T2DM patients. High glucose treatment (50\u2009mmol\/L) can upregulate the expression of TIPE2 and cytokine secretion in differentiated THP-1 cells. siTIPE2 infection exacerbated the increased TNF-<jats:italic>\u03b1<\/jats:italic> and IL-6 concentrations in differentiated THP-1 cells under high glucose conditions (50\u2009mmol\/L), while infection with TIPE2 adenovirus reversed the increased TNF-<jats:italic>\u03b1<\/jats:italic> concentration. <jats:italic>Conclusions<\/jats:italic>. The present study indicates that TIPE2 may participate in T2DM by regulating TNF-<jats:italic>\u03b1<\/jats:italic> production.<\/jats:p>","DOI":"10.1155\/2017\/4802319","type":"journal-article","created":{"date-parts":[[2017,5,24]],"date-time":"2017-05-24T17:01:47Z","timestamp":1495645307000},"page":"1-10","source":"Crossref","is-referenced-by-count":9,"title":["Upregulation of Tumor Necrosis Factor-<i>\u03b1<\/i>-Induced Protein 8-Like 2 mRNA Is Negatively Correlated with Serum Concentrations of Tumor Necrosis Factor-<i>\u03b1<\/i> and Interleukin 6 in Type 2 Diabetes Mellitus"],"prefix":"10.1155","volume":"2017","author":[{"given":"Yongliang","family":"Liu","sequence":"first","affiliation":[{"name":"Central of Translation Medicine, Zibo Central Hospital Affiliated to Shandong University, Zibo 255036, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinmei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Zibo Central 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