{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T13:21:51Z","timestamp":1784035311582,"version":"3.55.0"},"reference-count":11,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Rheumatology"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>Dermatomyositis (DM), a myopathy associated with inflammation and muscle weakness, has historically been difficult to diagnose. Recently, nuclear matrix protein (NXP-2) antibodies have been described as a myositis-specific antibody that may aid in the diagnostic evaluation. We present the case of a 21-year-old, previously healthy, African American male with DM. He presented to our outpatient clinic with periorbital swelling and a rash, for which he was started on prednisone by an ophthalmologist. Towards the end of the prednisone taper, he began to experience muscle weakness, a worsening rash, and dysphagia to solids with a resultant loss of 60 pounds within a month. He was transferred to a tertiary care hospital where he was further evaluated and ultimately diagnosed with dermatomyositis, supported by skin and muscle biopsies, and was found to be positive for NXP-2. He was given intravenous immunoglobulin (IVIG) and high-dose steroids with improvement.<\/jats:p>","DOI":"10.1155\/2017\/4817275","type":"journal-article","created":{"date-parts":[[2017,6,13]],"date-time":"2017-06-13T17:03:07Z","timestamp":1497373387000},"page":"1-4","source":"Crossref","is-referenced-by-count":7,"title":["NXP-2 Positive Dermatomyositis: A Unique Clinical Presentation"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9739-3506","authenticated-orcid":true,"given":"Zeeshan","family":"Butt","sequence":"first","affiliation":[{"name":"Internal Medicine Residency Program, Prince George\u2019s Hospital Center, 3001 Hospital Dr, Cheverly, MD 20785, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leeza","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, University of Arkansas for Medical Sciences, Little Rock, AR, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manash K.","family":"Das","sequence":"additional","affiliation":[{"name":"Internal Medicine Residency Program, Prince George\u2019s Hospital Center, 3001 Hospital Dr, Cheverly, MD 20785, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher A.","family":"Mecoli","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, John Hopkins University School of Medicine, 733 N Broadway, Baltimore, MD 21205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alim","family":"Ramji","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, John Hopkins University School of Medicine, 733 N Broadway, Baltimore, MD 21205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)05157-0"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2006.07.001"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-015-0120-1"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197502202920807"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197502132920706"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2011.39"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1186\/ar3822"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1002\/art.38093"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-200697"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23210"},{"key":"11","year":"2017","journal-title":"Arthritis care & research"}],"updated-by":[{"DOI":"10.1155\/2018\/1041738","type":"corrigendum","label":"Corrigendum","source":"publisher","updated":{"date-parts":[[2018,9,9]],"date-time":"2018-09-09T00:00:00Z","timestamp":1536451200000}}],"container-title":["Case Reports in Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crirh\/2017\/4817275.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crirh\/2017\/4817275.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crirh\/2017\/4817275.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,13]],"date-time":"2017-06-13T17:03:08Z","timestamp":1497373388000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/crirh\/2017\/4817275\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":11,"alternative-id":["4817275","4817275"],"URL":"https:\/\/doi.org\/10.1155\/2017\/4817275","relation":{"corrigendum":[{"id-type":"doi","id":"10.1155\/2018\/1041738","asserted-by":"object"}]},"ISSN":["2090-6889","2090-6897"],"issn-type":[{"value":"2090-6889","type":"print"},{"value":"2090-6897","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}