{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T19:12:58Z","timestamp":1792091578013,"version":"4.4.0"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,10,17]],"date-time":"2017-10-17T00:00:00Z","timestamp":1508198400000},"content-version":"vor","delay-in-days":289,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"publisher","award":["NSC 100-2313-B-235-001-MY3"],"award-info":[{"award-number":["NSC 100-2313-B-235-001-MY3"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p>\n                    Diabetic encephalopathy (DE) is often a complication in patients with Alzheimer\u2019s disease due to high blood sugar induced by diabetic mellitus. Ergothioneine (EGT) and hispidin (HIP) are antioxidants present in\n                    <jats:italic>Phellinus linteus.<\/jats:italic>\n                    Methylglyoxal (MGO), a toxic precursor of advanced glycated end products (AGEs), is responsible for protein glycation. We investigated whether a combination EGT and HIP (EGT\u2009+\u2009HIP) protects against MGO\u2010induced neuronal cell damage. Rat pheochromocytoma (PC12) cells were preincubated with EGT (2\u2009\n                    <jats:italic>\u03bc<\/jats:italic>\n                    M), HIP (2\u2009\n                    <jats:italic>\u03bc<\/jats:italic>\n                    M), or EGT\u2009+\u2009HIP, then challenged with MGO under high\u2010glucose condition (30\u2009\n                    <jats:italic>\u03bc<\/jats:italic>\n                    M MGO\u2009+\u200930\u2009mM glucose; GLU\u2009+\u2009MGO) for 24\u201396\u2009h. GLU\u2009+\u2009MGO markedly increased protein carbonyls and reactive oxygen species in PC12 cells; both of these levels were strongly reduced by EGT or HIP with effects comparable to those of 100\u2009nM aminoguanidine (an AGE inhibitor) but stronger than those of 10\u2009\n                    <jats:italic>\u03bc<\/jats:italic>\n                    M epalrestat (an aldose reductase inhibitor). GLU\u2009+\u2009MGO significantly increased the levels of AGE and AGE receptor (RAGE) protein expression of nuclear factor kappa\u2010B (NF\u2010\n                    <jats:italic>\u03ba<\/jats:italic>\n                    B) in the cytosol, but treatment with EGT, HIP, or EGT\u2009+\u2009HIP significantly attenuated these levels. These results suggest that EGT and HIP protect against hyperglycemic damage in PC12 cells by inhibiting the NF\u2010\n                    <jats:italic>\u03ba<\/jats:italic>\n                    B transcription pathway through antioxidant activities.\n                  <\/jats:p>","DOI":"10.1155\/2017\/4824371","type":"journal-article","created":{"date-parts":[[2017,10,17]],"date-time":"2017-10-17T19:31:00Z","timestamp":1508268660000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Protective Effects and Possible Mechanisms of Ergothioneine and Hispidin against Methylglyoxal\u2010Induced Injuries in Rat Pheochromocytoma Cells"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5010-7226","authenticated-orcid":false,"given":"Tuzz-Ying","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nae-Cherng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0277-1039","authenticated-orcid":false,"given":"Chien-Lin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thuy Lan Vo","family":"Thi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,10,17]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-004-0552-1"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.61.5.661"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0006-8993(02)02887-1"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.5.1497"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0306-4522(03)00343-9"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000322087"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.2174\/156652407783220705"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2007.07.019"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600415"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1042\/CS20050026"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/674987"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)71044-2"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2012.08.004"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1997.6109"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2011.09.017"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0304-3940(02)00427-5"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2003.11.005"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2010.09.030"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2012.08.021"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.3109\/10715762.2014.920954"},{"key":"e_1_2_8_21_2","first-page":"667","article-title":"Inhibition of chemiluminescence response of human mononuclear cells and suppression of mitogen-induced proliferation of spleen lymphocytes of mice by hispolon and hispidin","volume":"51","author":"Ali N. 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