{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:27:17Z","timestamp":1761060437514,"version":"3.37.3"},"reference-count":37,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["104-2221-E-006-271-MY2"],"award-info":[{"award-number":["104-2221-E-006-271-MY2"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contrast Media &amp; Molecular Imaging"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>The purpose of this study was to investigate if a novel parameter, the stress-to-rest ratio of the signal-to-noise ratio (RSNR) obtained with a cadmium zinc telluride (CZT) SPECT scanner, could be used to distinguish triple-vessel disease (TVD) patients.<jats:italic> Methods<\/jats:italic>. One hundred and two patients with suspected coronary artery disease were retrospectively involved. Each subject underwent a Tl-201 SPECT scan and subsequent coronary angiography. Subjects were separated into TVD (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">41<\/mml:mn><\/mml:math>) and control (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">61<\/mml:mn><\/mml:math>) groups based on coronary angiography results using 50% as the stenosis cutoff. The RSNR was calculated by dividing the stress signal-to-noise ratio (SNR) by the rest SNR. Summed scores were calculated using quantitative perfusion SPECT (QPS) for all subjects.<jats:italic> Results<\/jats:italic>. The RSNR in the TVD group was found to be significantly lower than that in the control group (0.83 \u00b1 0.15 and 1.06 \u00b1 0.17, resp.; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.01<\/mml:mn><\/mml:math>). Receiver-operating characteristic (ROC) analysis showed that RSNR can detect TVD more accurately than the summed difference score with higher sensitivity (85% versus 68%), higher specificity (90% versus 72%), and higher accuracy (88% versus 71%).<jats:italic> Conclusion<\/jats:italic>. The RSNR may serve as a useful index to assist the diagnosis of TVD when a fully automatic quantification method is used in CZT-based SPECT studies.<\/jats:p>","DOI":"10.1155\/2017\/4945680","type":"journal-article","created":{"date-parts":[[2017,10,15]],"date-time":"2017-10-15T19:32:57Z","timestamp":1508095977000},"page":"1-8","source":"Crossref","is-referenced-by-count":2,"title":["Detecting Triple-Vessel Disease with Cadmium Zinc Telluride-Based Single-Photon Emission Computed Tomography Using the Intensity Signal-to-Noise Ratio between Rest and Stress Studies"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1039-7983","authenticated-orcid":true,"given":"Yu-Hua Dean","family":"Fang","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, National Cheng Kung University, Tainan, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tzu-Pei","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Chang Gung Memorial Hospital, Keelung, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi-Jen","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Chang Gung Memorial Hospital, Linkou, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kung-Chu","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Chang Gung Memorial Hospital, Linkou, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"May","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, National Cheng Kung University, Tainan, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6136-0486","authenticated-orcid":true,"given":"Tzu-Chen","family":"Yen","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Chang Gung Memorial Hospital, Linkou, Taiwan"},{"name":"Center for Advanced Molecular Imaging and Translation & Cyclotron Center, Chang Gung Memorial Hospital, Linkou, 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