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As a small molecule, OTX008 serves as a selective inhibitor of Gal-1. In this study, the role of Gal-1 and the antiangiogenic effect of OTX008 on retinal neovascularization (RNV) were investigated using a mouse model of oxygen-induced retinopathy. The outcome indicated that Gal-1 was overexpressed and closely related to retinal neovessels in OIR. After intravitreal injection of OTX008 at P12, the RNV was significantly reduced at P17, measuring by cross-sectional H&amp;E staining and whole-mount fluorescence. Our results demonstrate the inhibitory function of OTX008 on RNV, which provides a promising strategy of treating retinal angiogenic diseases such as retinopathy of prematurity and proliferative diabetic retinopathy.<\/jats:p>","DOI":"10.1155\/2017\/5053035","type":"journal-article","created":{"date-parts":[[2017,3,27]],"date-time":"2017-03-27T17:51:10Z","timestamp":1490637070000},"page":"1-12","source":"Crossref","is-referenced-by-count":8,"title":["Suppression of Retinal Neovascularization by Inhibition of Galectin-1 in a Murine Model of Oxygen-Induced Retinopathy"],"prefix":"10.1155","volume":"2017","author":[{"given":"Ning","family":"Yang","sequence":"first","affiliation":[{"name":"Eye Center, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan, Hubei Province 430060, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenxi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Eye Center, Renmin Hospital of Wuhan University, 238 Jiefang 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