{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T15:53:57Z","timestamp":1782921237250,"version":"3.54.5"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,8,30]],"date-time":"2017-08-30T00:00:00Z","timestamp":1504051200000},"content-version":"vor","delay-in-days":241,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Sri Lankan treasury","award":["TG 11\/60"],"award-info":[{"award-number":["TG 11\/60"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p>Ethanol (95%) and dichloromethane\u2009:\u2009methanol (DCM\u2009:\u2009M, 1\u2009:\u20091 v\/v) bark extracts (BEs) and leaf extracts (LEs) of authenticated Ceylon cinnamon (CC) were studied for antiamylase, antiglucosidase, anticholinesterases, and antiglycation and glycation reversing potential in bovine serum albumin\u2010 (BSA\u2010) glucose and BSA\u2010methylglyoxal models in vitro<jats:italic>.<\/jats:italic> Further, total proanthocyanidins (TP) were quantified. Results showed significant differences (<jats:italic>p<\/jats:italic> &lt; 0.05) between bark and leaf extracts for the studied biological activities (except antiglucosidase) and TP. BEs showed significantly high (<jats:italic>p<\/jats:italic> &lt; 0.05) activities for antiamylase (IC<jats:sub>50<\/jats:sub>: 214 \u00b1 2\u2013215 \u00b1 10\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL), antibutyrylcholinesterase (IC<jats:sub>50<\/jats:sub>: 26.62 \u00b1 1.66\u201336.09 \u00b1 0.83\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL), and glycation reversing in BSA\u2010glucose model (EC<jats:sub>50<\/jats:sub>: 94.33 \u00b1 1.81\u2013107.16 \u00b1 3.95\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL) compared to LEs. In contrast, glycation reversing in BSA\u2010methylglyoxal (EC<jats:sub>50<\/jats:sub>: ethanol: 122.15 \u00b1 6.01\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL) and antiglycation in both BSA\u2010glucose (IC<jats:sub>50<\/jats:sub>: ethanol: 15.22 \u00b1 0.47\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL) and BSA\u2010methylglyoxal models (IC<jats:sub>50<\/jats:sub>: DCM\u2009:\u2009M: 278.29 \u00b1 8.55\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL) were significantly high (<jats:italic>p<\/jats:italic> &lt; 0.05) in leaf. Compared to the reference drugs used some of the biological activities were significantly (<jats:italic>p<\/jats:italic> &lt; 0.05) high (BEs: BChE inhibition and ethanol leaf: BSA\u2010glucose mediated antiglycation), some were comparable (BEs: BSA\u2010glucose mediated antiglycation), and some were moderate (BEs and LEs: antiamylase, AChE inhibition, and BSA\u2010MGO mediated antiglycation; DCM\u2009:\u2009M leaf: BSA\u2010glucose mediated antiglycation). TP were significantly high (<jats:italic>p<\/jats:italic> &lt; 0.05) in BEs compared to LEs (BEs and LEs: 1097.90 \u00b1 73.01\u20131381.53 \u00b1 45.93 and 309.52 \u00b1 2.81\u2013434.24 \u00b1 14.12\u2009mg cyanidin equivalents\/g extract, resp.). In conclusion, both bark and leaf of CC possess antidiabetic properties and thus may be useful in managing diabetes and its complications.<\/jats:p>","DOI":"10.1155\/2017\/5076029","type":"journal-article","created":{"date-parts":[[2017,8,30]],"date-time":"2017-08-30T21:02:37Z","timestamp":1504126957000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Antiamylase, Anticholinesterases, Antiglycation, and Glycation Reversing Potential of Bark and Leaf of Ceylon Cinnamon (<i>Cinnamomum zeylanicum<\/i> Blume) In Vitro"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8761-6614","authenticated-orcid":false,"given":"Sirimal Premakumara Galbada","family":"Arachchige","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walimuni Prabhashini Kaushalya 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