{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T14:09:39Z","timestamp":1773324579889,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Pregnancy"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>Vitamin D-binding protein is a multifunctional serum protein with multiple actions related to normal health. Vitamin D-binding protein transports vitamin D and influences the metabolism of this key hormone but it also has additional immunomodulatory and actin-clearing properties. We investigated whether vitamin D-binding protein expression is altered in fetal growth restriction-associated placental dysfunction. Protein was extracted from 35 placentae derived from 17 healthy control subjects and 18 gestation-matched subjects with fetal growth restriction (FGR). FGR subjects were further subdivided as idiopathic (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">9<\/mml:mn><\/mml:math>) and nonidiopathic (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">9<\/mml:mn><\/mml:math>). Vitamin D-binding protein and 25(OH) vitamin D were measured by ELISA and normalized to protein concentration. The results showed significantly reduced levels of placental vitamin D-binding protein (control versus FGR,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.05<\/mml:mn><\/mml:math>, Student\u2019s<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mrow><mml:mi>t<\/mml:mi><\/mml:mrow><\/mml:math>-test) that were strongly associated with idiopathic fetal growth restriction (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.01<\/mml:mn><\/mml:math>, Kruskal-Wallis), whereas levels of vitamin D-binding protein were not associated with placental 25(OH) vitamin D stores (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.295<\/mml:mn><\/mml:math>, Pearson\u2019s correlation). As such, vitamin D-binding protein may be a factor in unexplained placental dysfunction associated with idiopathic fetal growth restriction and may potentially serve as a biomarker of this disease.<\/jats:p>","DOI":"10.1155\/2017\/5120267","type":"journal-article","created":{"date-parts":[[2017,2,16]],"date-time":"2017-02-16T07:02:23Z","timestamp":1487228543000},"page":"1-5","source":"Crossref","is-referenced-by-count":14,"title":["Placental Vitamin D-Binding Protein Expression in Human Idiopathic Fetal Growth Restriction"],"prefix":"10.1155","volume":"2017","author":[{"given":"Alice F.","family":"Wookey","sequence":"first","affiliation":[{"name":"Department of Maternal-Fetal Medicine, Pregnancy Research Centre, Royal Women\u2019s Hospital, Parkville, VIC 3052, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tejasvy","family":"Chollangi","sequence":"additional","affiliation":[{"name":"Department of Maternal-Fetal Medicine, Pregnancy Research Centre, Royal Women\u2019s Hospital, Parkville, VIC 3052, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah E. J.","family":"Yong","sequence":"additional","affiliation":[{"name":"Department of Maternal-Fetal Medicine, Pregnancy Research Centre, Royal Women\u2019s Hospital, Parkville, VIC 3052, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0132-9858","authenticated-orcid":true,"given":"Bill","family":"Kalionis","sequence":"additional","affiliation":[{"name":"Department of Maternal-Fetal Medicine, Pregnancy Research Centre, Royal Women\u2019s Hospital, Parkville, VIC 3052, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3070-6971","authenticated-orcid":true,"given":"Shaun P.","family":"Brennecke","sequence":"additional","affiliation":[{"name":"Department of Maternal-Fetal Medicine, Pregnancy Research Centre, Royal Women\u2019s Hospital, Parkville, VIC 3052, Australia"},{"name":"Department of Obstetrics and Gynaecology, University of Melbourne, Royal Women\u2019s Hospital, Parkville, VIC 3052, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2535-5134","authenticated-orcid":true,"given":"Padma","family":"Murthi","sequence":"additional","affiliation":[{"name":"Department of Maternal-Fetal Medicine, Pregnancy Research Centre, Royal Women\u2019s Hospital, Parkville, VIC 3052, Australia"},{"name":"Department of Obstetrics and Gynaecology, University of Melbourne, Royal Women\u2019s Hospital, Parkville, VIC 3052, Australia"},{"name":"Department of Medicine, School of Clinical Sciences, Monash University, Clayton, VIC 3168, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0553-9489","authenticated-orcid":true,"given":"Harry M.","family":"Georgiou","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, University of Melbourne, Royal Women\u2019s Hospital, Parkville, VIC 3052, 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