{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:48:56Z","timestamp":1787017736225,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Canadian Journal of Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>\n                    <jats:italic>Background.<\/jats:italic>\n                    Small for size syndrome (SFSS) is responsible for a high proportion of mortalities and morbidities following extended liver resection.\n                    <jats:italic>Aim.<\/jats:italic>\n                    The aim of this study was to establish a porcine model of SFSS.\n                    <jats:italic>Methods.<\/jats:italic>\n                    Twenty-four Landrace pigs underwent liver resection with a remnant liver volume of 50% (group A,\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                      <mml:mi>n<\/mml:mi>\n                      <mml:mo>=<\/mml:mo>\n                      <mml:mn fontstyle=\"italic\">8<\/mml:mn>\n                    <\/mml:math>\n                    ), 25% (group B,\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                      <mml:mi>n<\/mml:mi>\n                      <mml:mo>=<\/mml:mo>\n                      <mml:mn fontstyle=\"italic\">8<\/mml:mn>\n                    <\/mml:math>\n                    ), and 15% (group C,\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                      <mml:mi>n<\/mml:mi>\n                      <mml:mo>=<\/mml:mo>\n                      <mml:mn fontstyle=\"italic\">8<\/mml:mn>\n                    <\/mml:math>\n                    ). After resection, the animals were followed up for 8 days and clinical, laboratory, and histopathological outcomes were evaluated.\n                    <jats:italic>Results.<\/jats:italic>\n                    The survival rate was significantly lower in group C compared with the other groups (\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                      <mml:mi>p<\/mml:mi>\n                      <mml:mo>&lt;<\/mml:mo>\n                      <mml:mn fontstyle=\"italic\">0.001<\/mml:mn>\n                    <\/mml:math>\n                    ). The international normalized ratio, bilirubin, aspartate transaminase, alanine transaminase, and alkaline phosphatase levels increased shortly after surgery in groups B and C, but no change was observed in group A (\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                      <mml:mi>p<\/mml:mi>\n                      <mml:mo>&lt;<\/mml:mo>\n                      <mml:mn fontstyle=\"italic\">0.05<\/mml:mn>\n                    <\/mml:math>\n                    for all analyses). The histopathological findings in group A were mainly mild mitoses, in group B severe mitoses and hepatocyte ballooning, moderate congestion, and hemorrhage, along with mild necrosis, and in group C extended tissue damage with severe necrosis, hemorrhage, and congestion.\n                    <jats:italic>Conclusions.<\/jats:italic>\n                    Combination of clinical, laboratory, and histopathological evaluations is needed to confirm the diagnosis of SFSS. 75% liver resection in porcine model results in SFSS. 85% liver resection causes irreversible liver failure.\n                  <\/jats:p>","DOI":"10.1155\/2017\/5127178","type":"journal-article","created":{"date-parts":[[2017,8,29]],"date-time":"2017-08-29T17:01:52Z","timestamp":1504026112000},"page":"1-8","source":"Crossref","is-referenced-by-count":11,"title":["Establishing a Porcine Model of Small for Size Syndrome following Liver 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