{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T04:40:11Z","timestamp":1768711211230,"version":"3.49.0"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,1,26]],"date-time":"2017-01-26T00:00:00Z","timestamp":1485388800000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81303192"],"award-info":[{"award-number":["81303192"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p><jats:italic>Schisandra chinensis<\/jats:italic> (<jats:italic>S. chinensis<\/jats:italic>) is a traditional Chinese herbal medicine widely used for the treatment of liver disease, whose main active components are lignans. However, the action mechanisms of the lignans in <jats:italic>S. chinensis<\/jats:italic> remain unclear. This study aimed to investigate the protective effect and related molecular mechanism of <jats:italic>Schisandra<\/jats:italic> lignan extract (SLE) against carbon tetrachloride\u2010 (CCl<jats:sub>4<\/jats:sub>\u2010) induced acute liver injury in mice. Different doses of SLE at 50, 100, and 200\u2009mg\/kg were administered daily by gavage for 5 days before CCl<jats:sub>4<\/jats:sub> treatment. The results showed that SLE significantly decreased the activities of serum ALT\/AST and reduced liver pathologic changes induced by CCl<jats:sub>4<\/jats:sub>. Pretreatment with SLE not only decreased the content of MDA but increased SOD, GSH, and GSH\u2010Px activities in the liver, suggesting that SLE attenuated CCl<jats:sub>4<\/jats:sub>\u2010induced oxidative stress. The expression levels of inflammatory cytokines TNF\u2010a, IL\u20101<jats:italic>\u03b2<\/jats:italic>, and IL\u20106 were decreased after oral administration of SLE, probably because lignans inhibited the NF\u2010<jats:italic>\u03ba<\/jats:italic>B activity. Additionally, SLE also inhibited hepatocyte apoptosis by suppressing JNK activation and regulating Bcl\u20102\/Bax signaling pathways. In conclusion, these results suggested that SLE prevented CCl<jats:sub>4<\/jats:sub>\u2010induced liver injury through a combination of antioxidative stress, anti\u2010inflammation, and antihepatocyte apoptosis and alleviated inflammation and apoptosis by regulating the NF\u2010<jats:italic>\u03ba<\/jats:italic>B, JNK, and Bcl\u20102\/Bax signaling pathways.<\/jats:p>","DOI":"10.1155\/2017\/5140297","type":"journal-article","created":{"date-parts":[[2017,1,26]],"date-time":"2017-01-26T21:36:27Z","timestamp":1485466587000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["<i>Schisandra<\/i> Lignan Extract Protects against Carbon Tetrachloride\u2010Induced Liver Injury in Mice by Inhibiting Oxidative Stress and Regulating the NF\u2010<i>\u03ba<\/i>B and JNK Signaling 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