{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:05:45Z","timestamp":1776989145201,"version":"3.51.4"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,3,13]],"date-time":"2017-03-13T00:00:00Z","timestamp":1489363200000},"content-version":"vor","delay-in-days":71,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31372477"],"award-info":[{"award-number":["31372477"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Inflammation and pain are closely related to humans\u2019 and animals\u2019 health.<jats:italic>Resveratrol<\/jats:italic>(RSV) is a natural compound with various biological activities. The current study is aimed to evaluate the analgesic and anti\u2010inflammatory activities of RSV in vivo<jats:italic>. Materials and Methods<\/jats:italic>. The analgesic effects were assessed by the acetic acid\u2010induced writhing and hot plate tests. The anti\u2010inflammatory effects were determined using the xylene\u2010induced mouse ear oedema, the acetic acid\u2010induced rat pleurisy, and carrageenan\u2010induced rat synovitis tests, respectively.<jats:italic>Results<\/jats:italic>. The analgesic results showed that RSV could significantly inhibit the number of writhes and improve the time and pain threshold of mice standing on hot plate. The anti\u2010inflammatory results showed that RSV could inhibit the ear oedema of mice. In acetic acid\u2010induced pleurisy test, RSV could significantly inhibit the WBC and pleurisy exudates, could decrease the production of NO, and elevate the activity of SOD in serum. In carrageenan\u2010induced synovitis test, RSV could reduce the content of MDA and elevate the T\u2010SOD activity in serum; RSV could inhibit the expressions of TP, PGE2, NO, and MDA.<jats:italic>Conclusion<\/jats:italic>. Shortly, these results indicated that RSV had potent analgesic and anti\u2010inflammatory activities and could be a potential new drug candidate for the treatment of inflammation and pain.<\/jats:p>","DOI":"10.1155\/2017\/5197567","type":"journal-article","created":{"date-parts":[[2017,3,13]],"date-time":"2017-03-13T21:38:50Z","timestamp":1489441130000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Analgesic and Anti\u2010Inflammatory Activities of Resveratrol through Classic Models in Mice and Rats"],"prefix":"10.1155","volume":"2017","author":[{"given":"Guangxi","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiqiang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiankun","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiuting","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renyong","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanfeng","family":"Zou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lixia","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5802-7829","authenticated-orcid":false,"given":"Zhongqiong","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,13]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01320"},{"key":"e_1_2_8_2_2","first-page":"70","article-title":"Antinociceptive effect of selected Mexican traditional medicinal species","volume":"48","author":"Deciga-Campos M.","year":"2005","journal-title":"Proceedings of the Western Pharmacology Society"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2009.1128"},{"key":"e_1_2_8_4_2","first-page":"671","volume-title":"Goodman and Gilman\u2032s the Pharmacological Basis of Therapeutics","author":"Burke A.","year":"2006"},{"key":"e_1_2_8_5_2","first-page":"267","volume-title":"Ethnomedicine: A Source of Complementary Therapeutics","author":"Anilkumar M.","year":"2010"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2011.08.038"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2009.09.015"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(99)00410-5"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2008.00076.x"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2004.12.017"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2014.01.006"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2014.02.539"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2008.02.034"},{"key":"e_1_2_8_14_2","article-title":"Acetic acid for analgesic screening","volume":"18","author":"Koster R.","year":"1958","journal-title":"Federation Proceedings"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2004.01.010"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2012.02.032"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.4.1957-1964.2002"},{"key":"e_1_2_8_18_2","first-page":"1151","article-title":"NSAID-induced gastrointestinal damage and the design of GI-sparing NSAIDs","volume":"9","author":"Wallace J. 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