{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T05:43:59Z","timestamp":1772775839180,"version":"3.50.1"},"reference-count":57,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Redes Tem\u00e1ticas-SEP","award":["BUAP-CA-147"],"award-info":[{"award-number":["BUAP-CA-147"]}]},{"name":"Redes Tem\u00e1ticas-SEP","award":["FIS\/IMSS\/PROT\/G11\/980"],"award-info":[{"award-number":["FIS\/IMSS\/PROT\/G11\/980"]}]},{"DOI":"10.13039\/501100004881","name":"IMSS","doi-asserted-by":"crossref","award":["BUAP-CA-147"],"award-info":[{"award-number":["BUAP-CA-147"]}],"id":[{"id":"10.13039\/501100004881","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004881","name":"IMSS","doi-asserted-by":"crossref","award":["FIS\/IMSS\/PROT\/G11\/980"],"award-info":[{"award-number":["FIS\/IMSS\/PROT\/G11\/980"]}],"id":[{"id":"10.13039\/501100004881","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Cytokines play important roles in the physiopathology of dengue infection; therefore, the suppressors of cytokine signaling (<jats:italic>socs<\/jats:italic>) that control the type and timing of cytokine functions could be involved in the origin of immune alterations in dengue.<jats:italic>Objective<\/jats:italic>. To explore the association of cytokine and<jats:italic>socs<\/jats:italic>levels with disease severity in dengue patients.<jats:italic>Methods<\/jats:italic>. Blood samples of 48 patients with confirmed dengue infection were analyzed. Amounts of interleukins IL-2, IL-4, IL-6, and IL-10, interferon- (IFN-)<jats:italic>\u03b3<\/jats:italic>, and tumor necrosis factor- (TNF-)<jats:italic>\u03b1<\/jats:italic>were quantified by flow cytometry, and the relative expression of<jats:italic>socs1<\/jats:italic>and<jats:italic>socs3<\/jats:italic>mRNA was quantified by real-time RT-PCR.<jats:italic>Results<\/jats:italic>. Increased levels of IL-10 and socs3 and lower expression of<jats:italic>socs1<\/jats:italic>were found in patients with dengue hemorrhagic fever (DHF) with respect to those with dengue fever (DF) (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>). Negative correlations were found between<jats:italic>socs1<\/jats:italic>and both IL-10 and<jats:italic>socs3<\/jats:italic>(<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:math>). The cutoff values of<jats:italic>socs3<\/jats:italic>(&gt;199.8-fold),<jats:italic>socs1<\/jats:italic>(&lt;1.94-fold), and IL-10 (&gt;134\u2009pg\/ml) have the highest sensitivity and specificity to discriminate between DF and DHF.<jats:italic>Conclusion<\/jats:italic>. Simultaneous changes in IL-10 and<jats:italic>socs1\/socs3<\/jats:italic>could be used as prognostic biomarkers of dengue severity.<\/jats:p>","DOI":"10.1155\/2017\/5197592","type":"journal-article","created":{"date-parts":[[2017,7,30]],"date-time":"2017-07-30T17:02:15Z","timestamp":1501434135000},"page":"1-10","source":"Crossref","is-referenced-by-count":34,"title":["IL-10 and socs3 Are Predictive Biomarkers of Dengue Hemorrhagic Fever"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6490-1364","authenticated-orcid":true,"given":"Lilian Karem","family":"Flores-Mendoza","sequence":"first","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica de Oriente, HGZ5, Instituto Mexicano del Seguro Social, Km 4.5 Carretera Atlixco-Metepec, 74360 Metepec, PUE, Mexico"},{"name":"Departamento de Ciencias Qu\u00edmico Biol\u00f3gicas y Agropecuarias, Divisi\u00f3n de Ciencias e Ingenier\u00eda, Universidad de Sonora, 85880 Navojoa, SON, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tania","family":"Estrada-Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica de Oriente, HGZ5, Instituto Mexicano del Seguro Social, Km 4.5 Carretera Atlixco-Metepec, 74360 Metepec, PUE, Mexico"},{"name":"Departamento de Ciencias de la Salud, Universidad Popular Aut\u00f3noma del Estado de Puebla, 21 Sur 1103, 72410 Puebla, PUE, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia","family":"Sede\u00f1o-Monge","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias de la Salud, Universidad Popular Aut\u00f3noma del Estado de Puebla, 21 Sur 1103, 72410 Puebla, PUE, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margarita","family":"Moreno","sequence":"additional","affiliation":[{"name":"Hospital General de Zona No. 5, Instituto Mexicano del Seguro Social, Km 4.5 Carretera Atlixco-Metepec, 74360 Metepec, PUE, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda del Consuelo","family":"Manjarrez","sequence":"additional","affiliation":[{"name":"Hospital General de Zona No. 5, Instituto Mexicano del Seguro Social, Km 4.5 Carretera Atlixco-Metepec, 74360 Metepec, PUE, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guadalupe","family":"Gonz\u00e1lez-Ochoa","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias Qu\u00edmico Biol\u00f3gicas y Agropecuarias, Divisi\u00f3n de Ciencias e Ingenier\u00eda, Universidad de Sonora, 85880 Navojoa, SON, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lourdes","family":"Mill\u00e1n-P\u00e9rez Pe\u00f1a","sequence":"additional","affiliation":[{"name":"Laboratorio de Bioqu\u00edmica y Biolog\u00eda Molecular, Centro de Qu\u00edmica, Instituto de Ciencias, Benem\u00e9rita Universidad Aut\u00f3noma de Puebla, Edif. 103 F, CU-BUAP, San Manuel, 72570 Puebla, PUE, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9415-6011","authenticated-orcid":true,"given":"Julio","family":"Reyes-Leyva","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica de Oriente, HGZ5, Instituto Mexicano del Seguro Social, Km 4.5 Carretera Atlixco-Metepec, 74360 Metepec, PUE, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"issue":"5","key":"1","doi-asserted-by":"crossref","first-page":"743","DOI":"10.4269\/ajtmh.2012.12-0157","volume":"86","year":"2012","journal-title":"The American Journal of Tropical Medicine and Hygiene"},{"issue":"3, article e0003547","key":"3","volume":"9","year":"2015","journal-title":"PLoS Neglected Tropical Diseases"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.17226\/5702"},{"key":"5","year":"2009"},{"issue":"4","key":"6","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1128\/CMR.00035-09","volume":"22","year":"2009","journal-title":"Clinical Microbiology Reviews"},{"issue":"5","key":"7","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1097\/01.qco.0000244047.31135.fa","volume":"19","year":"2006","journal-title":"Current Opinion in Infectious Diseases"},{"issue":"8","key":"8","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1038\/nri3014","volume":"11","year":"2011","journal-title":"Nature Reviews. 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