{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:10:51Z","timestamp":1773274251423,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["PON PRISMA"],"award-info":[{"award-number":["PON PRISMA"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["PON04a2_A"],"award-info":[{"award-number":["PON04a2_A"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["U01 AG024904"],"award-info":[{"award-number":["U01 AG024904"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["W81X WH-12-2-0012"],"award-info":[{"award-number":["W81X WH-12-2-0012"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["PON PRISMA"],"award-info":[{"award-number":["PON PRISMA"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["PON04a2_A"],"award-info":[{"award-number":["PON04a2_A"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["U01 AG024904"],"award-info":[{"award-number":["U01 AG024904"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["W81X WH-12-2-0012"],"award-info":[{"award-number":["W81X WH-12-2-0012"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004007","name":"Instituto Nazionale di Fisica Nucleare","doi-asserted-by":"publisher","award":["PON PRISMA"],"award-info":[{"award-number":["PON PRISMA"]}],"id":[{"id":"10.13039\/501100004007","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004007","name":"Instituto Nazionale di Fisica Nucleare","doi-asserted-by":"publisher","award":["PON04a2_A"],"award-info":[{"award-number":["PON04a2_A"]}],"id":[{"id":"10.13039\/501100004007","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004007","name":"Instituto Nazionale di Fisica Nucleare","doi-asserted-by":"publisher","award":["U01 AG024904"],"award-info":[{"award-number":["U01 AG024904"]}],"id":[{"id":"10.13039\/501100004007","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004007","name":"Instituto Nazionale di Fisica Nucleare","doi-asserted-by":"publisher","award":["W81X WH-12-2-0012"],"award-info":[{"award-number":["W81X WH-12-2-0012"]}],"id":[{"id":"10.13039\/501100004007","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["PON PRISMA"],"award-info":[{"award-number":["PON PRISMA"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["PON04a2_A"],"award-info":[{"award-number":["PON04a2_A"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 AG024904"],"award-info":[{"award-number":["U01 AG024904"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["W81X WH-12-2-0012"],"award-info":[{"award-number":["W81X WH-12-2-0012"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"DOD","award":["PON PRISMA"],"award-info":[{"award-number":["PON PRISMA"]}]},{"name":"DOD","award":["PON04a2_A"],"award-info":[{"award-number":["PON04a2_A"]}]},{"name":"DOD","award":["U01 AG024904"],"award-info":[{"award-number":["U01 AG024904"]}]},{"name":"DOD","award":["W81X WH-12-2-0012"],"award-info":[{"award-number":["W81X WH-12-2-0012"]}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["PON PRISMA"],"award-info":[{"award-number":["PON PRISMA"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["PON04a2_A"],"award-info":[{"award-number":["PON04a2_A"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U01 AG024904"],"award-info":[{"award-number":["U01 AG024904"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["W81X WH-12-2-0012"],"award-info":[{"award-number":["W81X WH-12-2-0012"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","award":["PON PRISMA"],"award-info":[{"award-number":["PON PRISMA"]}],"id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","award":["PON04a2_A"],"award-info":[{"award-number":["PON04a2_A"]}],"id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","award":["U01 AG024904"],"award-info":[{"award-number":["U01 AG024904"]}],"id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","award":["W81X WH-12-2-0012"],"award-info":[{"award-number":["W81X WH-12-2-0012"]}],"id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computational and Mathematical Methods in Medicine"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>Neurodegenerative diseases affect brain morphology and connectivity, making complex networks a suitable tool to investigate and model their effects. Because of its stereotyped pattern Alzheimer\u2019s disease (AD) is a natural benchmark for the study of novel methodologies. Several studies have investigated the network centrality and segregation changes induced by AD, especially with a single subject approach. In this work, a holistic perspective based on the application of multiplex network concepts is introduced. We define and assess a diagnostic score to characterize the brain topology and measure the disease effects on a mixed cohort of 52 normal controls (NC) and 47 AD patients, from Alzheimer\u2019s Disease Neuroimaging Initiative (ADNI). The proposed topological score allows an accurate NC-AD classification: the average area under the curve (AUC) is 95% and the 95% confidence interval is 92%\u201399%. Besides, the combination of topological information and structural measures, such as the hippocampal volumes, was also investigated. Topology is able to capture the disease signature of AD and, as the methodology is general, it can find interesting applications to enhance our insight into disease with more heterogeneous patterns.<\/jats:p>","DOI":"10.1155\/2017\/5271627","type":"journal-article","created":{"date-parts":[[2017,3,2]],"date-time":"2017-03-02T16:00:38Z","timestamp":1488470438000},"page":"1-10","source":"Crossref","is-referenced-by-count":13,"title":["Topological Measurements of DWI Tractography for Alzheimer\u2019s Disease Detection"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0211-0783","authenticated-orcid":true,"given":"Nicola","family":"Amoroso","sequence":"first","affiliation":[{"name":"Universit\u00e0 degli Studi di Bari \u201cA. Moro\u201d, Via Orabona 4, 70123 Bari, Italy"},{"name":"Istituto Nazionale di Fisica Nucleare, Sezione di Bari, Via Orabona 4, 70123 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfonso","family":"Monaco","sequence":"additional","affiliation":[{"name":"Istituto Nazionale di Fisica Nucleare, Sezione di Bari, Via Orabona 4, 70123 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1372-3916","authenticated-orcid":true,"given":"Sabina","family":"Tangaro","sequence":"additional","affiliation":[{"name":"Istituto Nazionale di Fisica Nucleare, Sezione di Bari, Via Orabona 4, 70123 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alzheimer\u2019s Disease","family":"Neuroimaging Initiative","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"23","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2009.215"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl166"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1140\/epjp\/i2012-12135-6"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2575"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70072-2"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/s1474-4422(10)70223-4"},{"issue":"6","key":"2","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.jalz.2016.02.006","volume":"12","year":"2016","journal-title":"Alzheimer's & Dementia"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.01.048"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/60\/22\/8851"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.10.065"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.01.008"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.10.015"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22759"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.3233\/BEN-2009-0234"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2013.03.052"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2013.07.006"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2011.06.027"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1159\/000077817"},{"key":"1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp257"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2015.00048"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.06.002"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2014.04.037"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0509389103"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1038\/30918"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(02)00157-2"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1038\/nphys209"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.3539-11.2011"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2012.04.010"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4136-10.2010"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2014.04.038"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1109038108"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1089\/brain.2012.0137"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2013.02.020"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22830"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2016.07.005"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.physrep.2014.07.001"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1103\/physreve.87.062806"}],"container-title":["Computational and Mathematical Methods in Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2017\/5271627.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2017\/5271627.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2017\/5271627.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,25]],"date-time":"2017-06-25T07:47:01Z","timestamp":1498376821000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/cmmm\/2017\/5271627\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":37,"alternative-id":["5271627","5271627"],"URL":"https:\/\/doi.org\/10.1155\/2017\/5271627","relation":{},"ISSN":["1748-670X","1748-6718"],"issn-type":[{"value":"1748-670X","type":"print"},{"value":"1748-6718","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}