{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:50:31Z","timestamp":1771462231653,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Scientific World Journal"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p><jats:italic>Morus nigra<\/jats:italic>has been used popularly for several proposes, including diabetic. In an attempt to support medicinal value, the acute hypoglycemic, hypolipidemic, and antioxidant effects of the ethanolic extract of<jats:italic>Morus nigra<\/jats:italic>(EEMn 200 or 400\u2009mg\/kg b.w.) were evaluated in normal and alloxan-induced diabetic treated for 14 days. Serum biochemical and antioxidant analysis were performed at the end of experiment. Oral glucose tolerance test was performed at 10th and 15th days. Chromatographic analysis by HPLC-DAD of EEMn was performed. Insulin was used as positive control to glycemic metabolism as well as fenofibrate to lipid metabolism. EEMn (400\u2009mg\/kg\/day) reduced fasting and postprandial glycaemia, improved oral glucose tolerance, and reduced lipolysis and proteolysis in diabetic rats. EEMn decreased the blood levels of total cholesterol and increased HDL level when compared to the diabetic control rats. At higher levels, EEMn reduced triglycerides and VLDL levels in diabetic rats. Also, EEMn reduced malondialdehyde and increased the reduced glutathione levels in liver of diabetic rats. Chromatographic analysis identified the presence of the flavonoids rutin, isoquercetin, and kaempferitrin. Acute EEMn treatment reduced hyperglycemia, improved oral glucose tolerance, and minimized dyslipidemia and oxidative stress leading to a reduction in atherogenic index in alloxan-induced diabetic rats.<\/jats:p>","DOI":"10.1155\/2017\/5275813","type":"journal-article","created":{"date-parts":[[2017,4,16]],"date-time":"2017-04-16T21:00:51Z","timestamp":1492376451000},"page":"1-10","source":"Crossref","is-referenced-by-count":20,"title":["Brazilian<i>Morus nigra<\/i>Attenuated Hyperglycemia, Dyslipidemia, and Prooxidant Status in Alloxan-Induced Diabetic Rats"],"prefix":"10.1155","volume":"2017","author":[{"given":"Ivanildo I. da S.","family":"J\u00fanior","sequence":"first","affiliation":[{"name":"Department of Physiology and Pharmacology, Federal University of Pernambuco, Recife, PE, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Humberto de Moura","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Federal University of Pernambuco, Recife, PE, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u00e9bora C. R.","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Federal University of San Francisco Valley, Petrolina, PE, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruideglan de Alencar","family":"Barros","sequence":"additional","affiliation":[{"name":"Federal University of San Francisco Valley, Petrolina, PE, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fl\u00e1via Peixoto","family":"Albuquerque","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Federal University of Pernambuco, Recife, PE, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dion\u00edsio Henrique Amaral","family":"da Silva","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Federal University of Pernambuco, Recife, PE, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grasielly R.","family":"Souza","sequence":"additional","affiliation":[{"name":"Federal University of San Francisco Valley, Petrolina, PE, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nath\u00e1lia A. C.","family":"Souza","sequence":"additional","affiliation":[{"name":"Federal University of San Francisco Valley, Petrolina, PE, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2403-1026","authenticated-orcid":true,"given":"Larissa A.","family":"Rolim","sequence":"additional","affiliation":[{"name":"Federal University of San Francisco Valley, Petrolina, PE, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flaviane M. M.","family":"Silva","sequence":"additional","affiliation":[{"name":"Federal University of San Francisco Valley, Petrolina, PE, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gl\u00f3ria I. B. P.","family":"Duarte","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Federal University of Pernambuco, Recife, PE, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0867-1357","authenticated-orcid":true,"given":"Jackson R. G. da S.","family":"Almeida","sequence":"additional","affiliation":[{"name":"Federal University of San Francisco Valley, Petrolina, PE, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fl\u00e1vio Monteiro de","family":"Oliveira J\u00fanior","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Federal University of Pernambuco, Recife, PE, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dayane A.","family":"Gomes","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Federal University of Pernambuco, Recife, PE, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3317-6304","authenticated-orcid":true,"given":"Eduardo C.","family":"Lira","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Federal University of Pernambuco, Recife, PE, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","first-page":"S11","volume":"40","year":"2017","journal-title":"The Journal of Clinical and Applied Research and Education"},{"key":"2","year":"2015"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2012.07.026"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2013.08.051"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/653789"},{"key":"6","year":"2013"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2007.10.025"},{"issue":"1","key":"8","first-page":"96","volume":"30","year":"2011","journal-title":"Latin American Journal of Pharmacy"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.3797\/scipharm.1101-15"},{"issue":"6","key":"10","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1248\/yakushi1947.115.6_476","volume":"115","year":"1995","journal-title":"Yakugaku Zasshi"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2011.09.044"},{"issue":"2","key":"12","first-page":"244","volume":"15","year":"2012","journal-title":"Revista Brasileira de Plantas Medicinais"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1186\/1743-7075-8-85"},{"key":"14","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1093\/clinchem\/8.3.215","volume":"8","year":"1962","journal-title":"Clinical chemistry"},{"issue":"6","key":"15","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/clinchem\/18.6.499","volume":"18","year":"1972","journal-title":"Clinical Chemistry"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/s0895-4356(98)00139-5"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/182362"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdm.2011.01.004"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(78)90342-1"},{"issue":"1","key":"20","first-page":"158","volume":"70","year":"1967","journal-title":"The Journal of Laboratory and Clinical Medicine"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/S1098-3597(04)80054-1"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1021\/jf703709r"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.2298\/HEMIND111111002R"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0050619"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-007-0886-7"},{"issue":"5","key":"26","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/S2221-1691(12)60067-7","volume":"2","year":"2012","journal-title":"Asian Pacific Journal of Tropical Biomedicine"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.2337\/db10-1032"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1039\/c5fo00474h"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2014.06.011"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.10058"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2015.04.040"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1631\/jzus.B1000173"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.3390\/ijms13022472"},{"issue":"2","key":"34","first-page":"123","volume":"39","year":"2014","journal-title":"Iranian Journal of Medical Sciences"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2013.06.003"},{"issue":"3","key":"36","first-page":"215","volume":"51","year":"2014","journal-title":"Indian Journal of Biochemistry and Biophysics"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.3134"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1021\/jf1003607"}],"container-title":["The Scientific World Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/tswj\/2017\/5275813.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/tswj\/2017\/5275813.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/tswj\/2017\/5275813.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T15:11:55Z","timestamp":1601910715000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/tswj\/2017\/5275813\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":38,"alternative-id":["5275813","5275813"],"URL":"https:\/\/doi.org\/10.1155\/2017\/5275813","relation":{},"ISSN":["2356-6140","1537-744X"],"issn-type":[{"value":"2356-6140","type":"print"},{"value":"1537-744X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}