{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:52:40Z","timestamp":1761490360297,"version":"3.37.3"},"reference-count":14,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Comisi\u00f3n de Operaci\u00f3n y Fomento de Actividades Acad\u00e9micas del Instituto Polit\u00e9cnico Nacional"},{"name":"Est\u00edmulos al Desempe\u00f1o de los Investigadores del Instituto Polit\u00e9cnico Nacional"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computational and Mathematical Methods in Medicine"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>Therapeutic protocols in immunotherapy are usually proposed following the intuition and experience of the therapist. In order to deduce such protocols mathematical modeling, optimal control and simulations are used instead of the therapist\u2019s experience. Clinical efficacy of dendritic cell (DC) vaccines to cancer treatment is still unclear, since dendritic cells face several obstacles in the host environment, such as immunosuppression and poor transference to the lymph nodes reducing the vaccine effect. In view of that, we have created a mathematical murine model to measure the effects of dendritic cell injections admitting such obstacles. In addition, the model considers a therapy given by bolus injections of small duration as opposed to a continual dose. Doses timing defines the therapeutic protocols, which in turn are improved to minimize the tumor mass by an optimal control algorithm. We intend to supplement therapist\u2019s experience and intuition in the protocol\u2019s implementation. Experimental results made on mice infected with melanoma with and without therapy agree with the model. It is shown that the dendritic cells\u2019 percentage that manages to reach the lymph nodes has a crucial impact on the therapy outcome. This suggests that efforts in finding better methods to deliver DC vaccines should be pursued.<\/jats:p>","DOI":"10.1155\/2017\/5291823","type":"journal-article","created":{"date-parts":[[2017,8,20]],"date-time":"2017-08-20T17:01:52Z","timestamp":1503248512000},"page":"1-9","source":"Crossref","is-referenced-by-count":8,"title":["Dendritic Immunotherapy Improvement for an Optimal Control Murine Model"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8132-6341","authenticated-orcid":true,"given":"J. C.","family":"Rangel-Reyes","sequence":"first","affiliation":[{"name":"Laboratorio de Simulaci\u00f3n y Modelado, Centro de Investigaci\u00f3n en Computaci\u00f3n, Instituto Polit\u00e9cnico Nacional, Av. Juan de Dios B\u00e1tiz, Esq. Miguel Oth\u00f3n de Mendiz\u00e1bal, Col. Nueva Industrial Vallejo Delegaci\u00f3n Gustavo A. Madero, 07738 Ciudad de M\u00e9xico, Mexico"}]},{"given":"J. C.","family":"Chimal-Egu\u00eda","sequence":"additional","affiliation":[{"name":"Laboratorio de Simulaci\u00f3n y Modelado, Centro de Investigaci\u00f3n en Computaci\u00f3n, Instituto Polit\u00e9cnico Nacional, Av. Juan de Dios B\u00e1tiz, Esq. Miguel Oth\u00f3n de Mendiz\u00e1bal, Col. Nueva Industrial Vallejo Delegaci\u00f3n Gustavo A. Madero, 07738 Ciudad de M\u00e9xico, Mexico"}]},{"given":"E.","family":"Castillo-Montiel","sequence":"additional","affiliation":[{"name":"Laboratorio de Simulaci\u00f3n y Modelado, Centro de Investigaci\u00f3n en Computaci\u00f3n, Instituto Polit\u00e9cnico Nacional, Av. Juan de Dios B\u00e1tiz, Esq. Miguel Oth\u00f3n de Mendiz\u00e1bal, Col. Nueva Industrial Vallejo Delegaci\u00f3n Gustavo A. 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