{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:31:19Z","timestamp":1790771479740,"version":"4.1.0"},"reference-count":73,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>Systemic sclerosis is a chronic autoimmune connective tissue disease characterized by vascular injury and fibrosis and by an impaired angiogenesis which cannot ensure an efficient vascular recovery. Vascular injury is responsible for hypoxia and tissual ischemia which are the primary triggers for angiogenesis and are not able to induce a compensatory angiogenesis. This review article is focused on current knowledge on the mechanisms responsible for angiogenesis dysregulation in systemic sclerosis.<\/jats:p>","DOI":"10.1155\/2017\/5345673","type":"journal-article","created":{"date-parts":[[2017,7,16]],"date-time":"2017-07-16T17:03:04Z","timestamp":1500224584000},"page":"1-6","source":"Crossref","is-referenced-by-count":29,"title":["Angiogenesis Dysregulation in the Pathogenesis of Systemic Sclerosis"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9929-9177","authenticated-orcid":true,"given":"Francesco Paolo","family":"Cantatore","sequence":"first","affiliation":[{"name":"Rheumatology Clinic, Department of Medical and Surgical Sciences, University of Foggia Medical School, Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Maruotti","sequence":"additional","affiliation":[{"name":"Rheumatology Clinic, Department of Medical and Surgical Sciences, University of Foggia Medical School, Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Addolorata","family":"Corrado","sequence":"additional","affiliation":[{"name":"Rheumatology Clinic, Department of Medical and Surgical Sciences, University of Foggia Medical School, Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4768-8431","authenticated-orcid":true,"given":"Domenico","family":"Ribatti","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School, Bari, Italy"},{"name":"National Cancer Institute \u201cGiovanni Paolo II\u201d, Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-015-0505-5"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1002\/art.37988"},{"key":"3","first-page":"S19","volume":"22","year":"2004","journal-title":"Clinical and Experimental Rheumatology"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1186\/ar2186"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0806188"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2011.04.016"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2005.09.004"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2007.11.004"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.117119"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00272"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-011-0219-1"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/835948"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1038\/80533"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1002\/art.21952"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2007.12.004"},{"key":"16","first-page":"831","volume":"151","year":"1997","journal-title":"American Journal of Pathology"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1161\/hc0902.105719"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.150088"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-210229"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-015-0754-7"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-013-9338-9"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.02.029"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2006.12.006"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.072686"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kep716"},{"key":"26","first-page":"S30","volume":"30","year":"2012","journal-title":"Clinical and Experimental Rheumatology"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-014-0442-z"},{"key":"28","first-page":"557","volume":"21","year":"2006","journal-title":"Histology and Histopathology"},{"key":"29","first-page":"476","volume":"26","year":"2008","journal-title":"Clinical and Experimental Rheumatology"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2011.04.019"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1186\/ar596"},{"issue":"12","key":"32","first-page":"2565","volume":"29","year":"2002","journal-title":"The Journal of Rheumatology"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1186\/ar2002"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1002\/art.22861"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2016.60970"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-016-3483-7"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.2478\/v10039-011-0025-z"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203535"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.111.242057"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-015-0848-2"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1002\/art.21383"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keq392"},{"key":"43","first-page":"37","volume":"34","year":"2016","journal-title":"Clinical and Experimental Rheumatology"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1002\/art.22047"},{"key":"45","first-page":"641","volume":"20","year":"2002","journal-title":"Clinical and Experimental Rheumatology"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000134644.89917.96"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2005.10.007"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1002\/art.23968"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2011.1284"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1002\/art.21396"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1186\/ar3242"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kev399"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13341"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.1002\/art.25056"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63685-1"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2015.06.004"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.102624"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1002\/art.20562"},{"key":"59","doi-asserted-by":"publisher","DOI":"10.1002\/art.22263"},{"key":"60","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-12-129080"},{"key":"61","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.100237"},{"key":"62","doi-asserted-by":"publisher","DOI":"10.1002\/art.30101"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.1002\/art.39828"},{"key":"64","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1008544107"},{"key":"65","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-017-1233-0"},{"key":"66","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-015-0749-4"},{"key":"67","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-207483"},{"key":"68","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12111"},{"key":"69","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.22-3-377"},{"key":"70","doi-asserted-by":"publisher","DOI":"10.3727\/096368914X674062"},{"key":"71","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-12-0641"},{"key":"72","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-012-0202-z"},{"key":"73","doi-asserted-by":"publisher","DOI":"10.1186\/ar4070"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2017\/5345673.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2017\/5345673.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2017\/5345673.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,7,16]],"date-time":"2017-07-16T17:03:07Z","timestamp":1500224587000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/bmri\/2017\/5345673\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":73,"alternative-id":["5345673","5345673"],"URL":"https:\/\/doi.org\/10.1155\/2017\/5345673","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}