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It is still unknown whether Ang II can induce testicular apoptotic cell death, which may be a more direct action of Ang II in male infertility. Therefore, the present study aims to determine whether Ang II can induce testicular apoptotic cell death and whether this action can be prevented by sulforaphane (SFN) via activating nuclear factor (erythroid\u2010derived 2)\u2010like 2 (NRF2), the governor of antioxidant\u2010redox signalling. Eight\u2010week\u2010old male C57BL\/6J wild type (WT) and <jats:italic>Nrf2<\/jats:italic> gene knockout mice were treated with Ang II, in the presence or absence of SFN. In WT mice, SFN activated testicular NRF2 expression and function, along with a marked attenuation in Ang II\u2010induced testicular oxidative stress, inflammation, endoplasmic reticulum stress, and apoptotic cell death. Deletion of the <jats:italic>Nrf2<\/jats:italic> gene led to a complete abolishment of these efficacies of SFN. The present study indicated that Ang II may result in testicular apoptotic cell death, which can be prevented by SFN via the activation of NRF2.<\/jats:p>","DOI":"10.1155\/2017\/5374897","type":"journal-article","created":{"date-parts":[[2017,1,17]],"date-time":"2017-01-17T22:13:02Z","timestamp":1484691182000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Sulforaphane Prevents Angiotensin II\u2010Induced Testicular Cell Death via Activation of 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