{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:48:56Z","timestamp":1787017736396,"version":"build-2736575974"},"reference-count":59,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,1,19]],"date-time":"2017-01-19T00:00:00Z","timestamp":1484784000000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004054","name":"King Abdulaziz University","doi-asserted-by":"publisher","award":["503-130-1434"],"award-info":[{"award-number":["503-130-1434"]}],"id":[{"id":"10.13039\/501100004054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p>\n                    Gastric ulcers are a major problem worldwide with no effective treatment. The objective of this study was to evaluate the use of manuka honey in the treatment of acetic acid\u2010induced chronic gastric ulcers in rats. Different groups of rats were treated with three different concentrations of honey. Stomachs were checked macroscopically for ulcerative lesions in the glandular mucosa and microscopically for histopathological alterations. Treatment with manuka honey significantly reduced the ulcer index and maintained the glycoprotein content. It also reduced the mucosal myeloperoxidase activity, lipid peroxidation (MDA), and the inflammatory cytokines (TNF\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    , IL\u20101\n                    <jats:italic>\u03b2<\/jats:italic>\n                    , and IL\u20106) as compared to untreated control group. In addition, honey\u2010treated groups showed significant increase in enzymatic (GPx and SOD) and nonenzymatic (GSH) antioxidants besides levels of the anti\u2010inflammatory cytokine IL\u201010. Flow cytometry studies showed that treatment of animals with manuka honey has normalized cell cycle distribution and significantly lowered apoptosis in gastric mucosa. In conclusion, the results indicated that manuka honey is effective in the treatment of chronic ulcer and preservation of mucosal glycoproteins. Its effects are due to its antioxidant and anti\u2010inflammatory properties that resulted in a significant reduction of the gastric mucosal MDA, TNF\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    , IL\u20101\n                    <jats:italic>\u03b2<\/jats:italic>\n                    , and IL\u20106 and caused an elevation in IL\u201010 levels.\n                  <\/jats:p>","DOI":"10.1155\/2017\/5413917","type":"journal-article","created":{"date-parts":[[2017,1,19]],"date-time":"2017-01-19T17:31:26Z","timestamp":1484847086000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":74,"title":["Manuka Honey Exerts Antioxidant and Anti\u2010Inflammatory Activities That Promote Healing of Acetic Acid\u2010Induced Gastric Ulcer in Rats"],"prefix":"10.1155","volume":"2017","author":[{"given":"Saad B.","family":"Almasaudi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7372-370X","authenticated-orcid":false,"given":"Aymn T.","family":"Abbas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashad R.","family":"Al-Hindi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2593-6879","authenticated-orcid":false,"given":"Nagla A.","family":"El-Shitany","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umama A.","family":"Abdel-dayem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soad S.","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasha M.","family":"Saleh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soad K.","family":"Al Jaouni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0088-0565","authenticated-orcid":false,"given":"Mohammad Amjad","family":"Kamal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7512-8787","authenticated-orcid":false,"given":"Steve M.","family":"Harakeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,1,19]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2013.11.011"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1023\/a:1026040723669"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.10.7.8635690"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/smj.0b013e31826efbea"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2009.125"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.4291\/wjgp.v5.i1.40"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(09)60938-7"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i22.2710"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2012.09.026"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2221-1691(11)60016-6"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/0005772x.2001.11099498"},{"key":"e_1_2_8_12_2","first-page":"731","article-title":"Traditional and modern uses of natural honey in human diseases: a review","volume":"16","author":"Eteraf-Oskouei T.","year":"2013","journal-title":"Iranian Journal of Basic Medical Sciences"},{"key":"e_1_2_8_13_2","volume-title":"Beekeeping in the United States Agriculture Handbook","author":"White J. W.","year":"1980"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2006.09.013"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules200916068"},{"key":"e_1_2_8_16_2","unstructured":"Chemical Composition of Honey http:\/\/www.chm.bris.ac.uk\/webprojects2001\/loveridge\/index-page3.html."},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.12968\/bjom.2014.22.2.111"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/3643824"},{"key":"e_1_2_8_19_2","first-page":"628","article-title":"The coloration of acidic carbohydrates of bacteria and fungi in tissue sections with special reference to capsules of Cryptococcus neoformans, Pneumococci, and Staphylococci","volume":"32","author":"Mowry R.","year":"1956","journal-title":"American Journal of Pathology"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(90)86172-r"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2012.09.019"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.19.418"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-007-9949-3"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(59)90090-6"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(78)90342-1"},{"key":"e_1_2_8_26_2","first-page":"158","article-title":"Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase","volume":"70","author":"Paglia D. E.","year":"1967","journal-title":"The Journal of Laboratory and Clinical Medicine"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(72)80218-3"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0076-6879(84)05016-3"},{"key":"e_1_2_8_29_2","first-page":"621","article-title":"Does cholecystectomy affect antral mucosa? Endoscopic, histopathologic and DNA flow cytometric study","volume":"47","author":"Abdel-Wahab M.","year":"1999","journal-title":"Hepato-Gastroenterology"},{"key":"e_1_2_8_30_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/313798"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.28.1321"},{"key":"e_1_2_8_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2012.06.001"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/bf02235252"},{"key":"e_1_2_8_34_2","doi-asserted-by":"publisher","DOI":"10.1023\/b:ifla.0000006703.53427.da"},{"key":"e_1_2_8_35_2","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2010.25.6.875"},{"key":"e_1_2_8_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/sc.2011.87"},{"key":"e_1_2_8_37_2","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2004.13.5.26614"},{"key":"e_1_2_8_38_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.asw.0000345283.05532.9a"},{"key":"e_1_2_8_39_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/218283"},{"key":"e_1_2_8_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0891-5849(98)00179-8"},{"key":"e_1_2_8_41_2","first-page":"349","article-title":"Characterization of \u2018unhealed gastric ulcers\u2019 produced with chronic exposure of acetic acid ulcers to indomethacin in rats","volume":"54","author":"Amagase K.","year":"2003","journal-title":"Journal of Physiology and Pharmacology"},{"key":"e_1_2_8_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2010.04.014"},{"key":"e_1_2_8_43_2","doi-asserted-by":"publisher","DOI":"10.31989\/ffhd.v2i3.99"},{"key":"e_1_2_8_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(88)90623-6"},{"key":"e_1_2_8_45_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkl336"},{"key":"e_1_2_8_46_2","doi-asserted-by":"publisher","DOI":"10.1080\/003655200750023697"},{"key":"e_1_2_8_47_2","first-page":"39","article-title":"Effects of reactive oxygen species action on gastric mucosa in various models of mucosal injury","volume":"53","author":"Kwiecie\u0144 S.","year":"2002","journal-title":"Journal of Physiology and Pharmacology"},{"key":"e_1_2_8_48_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1993.265.5.G993"},{"key":"e_1_2_8_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(91)90259-N"},{"key":"e_1_2_8_50_2","first-page":"82","article-title":"Protective effect of natural honey against acetic acid-induced colitis in rats","volume":"23","author":"Mahgoub A. A.","year":"2002","journal-title":"Tropical Gastroenterology"},{"key":"e_1_2_8_51_2","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.2523"},{"key":"e_1_2_8_52_2","doi-asserted-by":"publisher","DOI":"10.1177\/1753425911422263"},{"key":"e_1_2_8_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nutres.2010.08.008"},{"key":"e_1_2_8_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2009.03.015"},{"key":"e_1_2_8_55_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i13.2034"},{"key":"e_1_2_8_56_2","first-page":"880","article-title":"Cellular proliferation and ploidy of the gastric mucosa: the role of Helicobacter pylori","volume":"44","author":"Abdel-Wahab M.","year":"1997","journal-title":"Hepato-Gastroenterology"},{"key":"e_1_2_8_57_2","first-page":"1305","article-title":"Apoptosis in chronic gastritis: evaluation of the gastric mucosa by DNA flow cytometry and the expression of the high molecular weight cytokeratin","volume":"43","author":"Attallah A. M.","year":"1996","journal-title":"Hepato-Gastroenterology"},{"key":"e_1_2_8_58_2","doi-asserted-by":"publisher","DOI":"10.1080\/15216549700202631"},{"key":"e_1_2_8_59_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.44.4.456"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2017\/5413917.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2017\/5413917.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2017\/5413917","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T22:05:34Z","timestamp":1722895534000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2017\/5413917"}},"subtitle":[],"editor":[{"given":"Jos\u00e9 Maur\u00edcio","family":"Sforcin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":59,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1155\/2017\/5413917"],"URL":"https:\/\/doi.org\/10.1155\/2017\/5413917","archive":["Portico"],"relation":{},"ISSN":["1741-427X","1741-4288"],"issn-type":[{"value":"1741-427X","type":"print"},{"value":"1741-4288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"2016-07-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-11-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-01-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"5413917"}}