{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T15:42:24Z","timestamp":1767109344254,"version":"3.37.3"},"reference-count":41,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Around 70\u201390% of peptic ulcer disease (PUD) is due to<jats:italic> Helicobacter pylori<\/jats:italic> and requires treatment with antimicrobials to which these bacteria are susceptible. Common<jats:italic> H. pylori<\/jats:italic> diagnostic tests do not provide drug susceptibility data. Using the GenoType HelicoDR PCR test designed for gastric biopsies for simultaneous detection of<jats:italic> H. pylori<\/jats:italic> and its resistance to clarithromycin (CLA)\/fluoroquinolones (FLQ), we present evidence for stool as an optional test specimen and also provide data on prevalence of<jats:italic> H. pylori<\/jats:italic> resistance to CLA and FLQ in Uganda.<jats:italic> Methods<\/jats:italic>. Stool from 142 symptomatic PUD patients at three hospitals in Kampala was screened for<jats:italic> H. pylori<\/jats:italic> using a rapid antigen test. The GenoType HelicoDR test was run on all<jats:italic> H. pylori<\/jats:italic> antigen positives to determine PCR positivity and resistance to CLA\/FLQ.<jats:italic> Results<\/jats:italic>. Thirty-one samples (22%) were<jats:italic> H. pylori<\/jats:italic> antigen positive, and 21 (68%) of these were<jats:italic> H. pylori<\/jats:italic> PCR positive. Six of the 21 (29%) were resistant to CLA and eight to FLQ (42%), while two gave invalid FLQ resistance results.<jats:italic> Conclusion<\/jats:italic>. Stool is a possible specimen for the GenoType HelicoDR test for rapid detection of<jats:italic> H. pylori<\/jats:italic> and drug resistance. In Uganda,<jats:italic> Helicobacter pylori<\/jats:italic> is highly resistant to CLA and FLQ.<\/jats:p>","DOI":"10.1155\/2017\/5430723","type":"journal-article","created":{"date-parts":[[2017,5,7]],"date-time":"2017-05-07T17:00:45Z","timestamp":1494176445000},"page":"1-9","source":"Crossref","is-referenced-by-count":11,"title":["<i>Helicobacter pylori<\/i> from Peptic Ulcer Patients in Uganda Is Highly Resistant to Clarithromycin and Fluoroquinolones: Results of the GenoType HelicoDR Test Directly Applied on Stool"],"prefix":"10.1155","volume":"2017","author":[{"given":"Denish Calmax","family":"Angol","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology, Makerere University College of Health Sciences, P.O. Box 7072, Kampala, Uganda"},{"name":"Department of Midwifery, Faculty of Health Sciences, Lira University, P.O. 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