{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:57:42Z","timestamp":1775782662859,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003645","name":"National Cancer Center","doi-asserted-by":"publisher","award":["1610210"],"award-info":[{"award-number":["1610210"]}],"id":[{"id":"10.13039\/501100003645","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003645","name":"National Cancer Center","doi-asserted-by":"publisher","award":["1310360"],"award-info":[{"award-number":["1310360"]}],"id":[{"id":"10.13039\/501100003645","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003645","name":"National Cancer Center","doi-asserted-by":"publisher","award":["1610210"],"award-info":[{"award-number":["1610210"]}],"id":[{"id":"10.13039\/501100003645","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003645","name":"National Cancer Center","doi-asserted-by":"publisher","award":["1310360"],"award-info":[{"award-number":["1310360"]}],"id":[{"id":"10.13039\/501100003645","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p><jats:italic>Objective. <\/jats:italic>The purpose of this study was to (i) determine the cervical microbial composition in different abortion samples and to (ii) investigate the correlation between spontaneous abortion and cervical microbes in Korean women.<jats:italic> Methods. <\/jats:italic>We collected cervical swabs from women who had never undergone abortion (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>N<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">36<\/mml:mn><\/mml:math>), had spontaneous abortion (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>N<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">23<\/mml:mn><\/mml:math>), and had undergone induced abortion (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>N<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">88<\/mml:mn><\/mml:math>) and subjected those samples to 16S rRNA pyrosequencing. Further, factor analysis and correlation between cervical microbiota and spontaneous abortion were evaluated by logistic regression analysis.<jats:italic> Results. <\/jats:italic>In spontaneous abortion women, 16 S rRNA gene sequences showed significant increases in<jats:italic> Atopobium vaginae<\/jats:italic>,<jats:italic> Megasphaera<\/jats:italic> spp.,<jats:italic> Gardnerella vaginalis<\/jats:italic>,<jats:italic> Leptotrichia amnionii<\/jats:italic>, and<jats:italic> Sneathia sanguinegens<\/jats:italic> compared to women in nonabortion group. In multivariate logistic regression analysis,<jats:italic> A. vaginae<\/jats:italic> (OD = 11.27; 95% = 1.57\u201381)<jats:italic>, L. amnionii<\/jats:italic> (OD = 11.47; 95% = 1.22\u2013107.94),<jats:italic> S. sanguinegens<\/jats:italic> (OD = 6.89; 95% = 1.07\u201344.33), and factor 1 microbes (OD = 16.4; 95% = 1.88\u201342.5) were strongly associated with spontaneous abortion.<jats:italic> Conclusions. <\/jats:italic>This study showed a high prevalence of<jats:italic> L. amnionii, A. vaginae, S. sanguinegens<\/jats:italic>, and factor 1 microbes in spontaneous abortion and association with spontaneous abortion in Korean women.<\/jats:p>","DOI":"10.1155\/2017\/5435089","type":"journal-article","created":{"date-parts":[[2017,12,13]],"date-time":"2017-12-13T18:31:25Z","timestamp":1513189885000},"page":"1-11","source":"Crossref","is-referenced-by-count":18,"title":["High Prevalence of<i> Leptotrichia amnionii<\/i>,<i> Atopobium vaginae<\/i>,<i> Sneathia sanguinegens<\/i>, and Factor 1 Microbes and Association of Spontaneous Abortion among Korean Women"],"prefix":"10.1155","volume":"2017","author":[{"given":"Sang Soo","family":"Seo","sequence":"first","affiliation":[{"name":"Division of Cancer Epidemiology and Management, Center for Uterine Cancer, National Cancer Center, Ilsandong-gu, Goyang, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selvaraj","family":"Arokiyaraj","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Management, Center for Uterine Cancer, National Cancer Center, Ilsandong-gu, Goyang, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5279-4162","authenticated-orcid":true,"given":"Mi Kyung","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Management, Center for Uterine Cancer, National Cancer Center, Ilsandong-gu, Goyang, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hea Young","family":"Oh","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Management, Center for Uterine Cancer, National Cancer Center, Ilsandong-gu, Goyang, Republic of Korea"},{"name":"Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minji","family":"Kwon","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Management, Center for Uterine Cancer, National Cancer Center, Ilsandong-gu, Goyang, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Sook","family":"Kong","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Management, Center for Uterine Cancer, National Cancer Center, Ilsandong-gu, Goyang, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moon Kyung","family":"Shin","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Management, Center for Uterine Cancer, National Cancer Center, Ilsandong-gu, Goyang, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye Lee","family":"Yu","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Management, Center for Uterine Cancer, National Cancer Center, Ilsandong-gu, Goyang, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Kwan","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, Republic of 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