{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T22:57:36Z","timestamp":1782860256468,"version":"3.54.5"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,1,31]],"date-time":"2017-01-31T00:00:00Z","timestamp":1485820800000},"content-version":"vor","delay-in-days":30,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Pediatrics"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p>\n                    Pitt\u2010Hopkins Syndrome (PTHS) is a rare genetic disorder caused by insufficient expression of the\n                    <jats:italic>TCF4<\/jats:italic>\n                    gene. Children with PTHS typically present with gastrointestinal disorders and early severe chronic constipation is frequently found (75%). Here we describe the case of a PTHS male 10\u2010year\u2010old patient with chronic constipation in whom Osteopathic Manipulative Treatment (OMT) resulted in improved bowel functions, as assessed by the diary, the QPGS\u2010Form A Section C questionnaire, and the Paediatric Bristol Stool Form Scale. The authors suggested that OMT may be a valid tool to improve the defecation frequency and reduce enema administration in PTHS patients.\n                  <\/jats:p>","DOI":"10.1155\/2017\/5437830","type":"journal-article","created":{"date-parts":[[2017,1,31]],"date-time":"2017-01-31T16:06:19Z","timestamp":1485878779000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Osteopathic Manipulative Treatment Limits Chronic Constipation in a Child with Pitt\u2010Hopkins Syndrome"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1898-1065","authenticated-orcid":false,"given":"Alessandro","family":"Aquino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattia","family":"Perini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8361-9145","authenticated-orcid":false,"given":"Silvia","family":"Cosmai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6475-531X","authenticated-orcid":false,"given":"Silvia","family":"Zanon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviana","family":"Pisa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7773-9717","authenticated-orcid":false,"given":"Carmine","family":"Castagna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6701-7638","authenticated-orcid":false,"given":"Stefano","family":"Uberti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,1,31]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.1086\/515583"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1086\/515582"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2013.32"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1159\/000335287"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e3181bd38a9"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/aur.1467"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(00)90047-7"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.113.3.e259"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.95.1.50"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199911000-00029"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0016-5085(03)00888-6"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijosm.2009.10.002"},{"key":"e_1_2_13_13_2","article-title":"Osteopathic manipulative treatment for colonic inertia","volume":"113","author":"Cohen-Lewe A.","year":"2013","journal-title":"The Journal of the American Osteopathic Association"},{"key":"e_1_2_13_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmpt.2009.08.016"},{"key":"e_1_2_13_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmpt.2006.11.005"},{"key":"e_1_2_13_16_2","volume-title":"Benchmarks for Training in Traditional\/Complementary and Alternative Medicine: Benchmarks for Training in Osteopathy","author":"World Health Organization","year":"2010"},{"key":"e_1_2_13_17_2","unstructured":"American Association of Colleges of Osteopathic Medicine (AACOM) Glossary of Osteopathic Terminology http:\/\/www.aacom.org\/news-and-events\/publications\/glossary-of-osteopathic-terminology."},{"key":"e_1_2_13_18_2","first-page":"67","article-title":"Pediatric functional gastrointestinal disorders: a questionnaire on pediatric gastrointestinal symptoms based on Rome III criteria","volume":"61","author":"Buonavolont\u00e0 R.","year":"2009","journal-title":"Minerva Pediatrica"},{"key":"e_1_2_13_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2010.04.040"},{"key":"e_1_2_13_20_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2001.00982.x"},{"key":"e_1_2_13_21_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.061"},{"key":"e_1_2_13_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12124"},{"key":"e_1_2_13_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2016.107"},{"key":"e_1_2_13_24_2","first-page":"291","volume-title":"Somatic Dysfunction in Osteopathic Family Medicine","author":"Nelson K. E.","year":"2007"},{"key":"e_1_2_13_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-0897-4_3"},{"key":"e_1_2_13_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2010.06.002"},{"key":"e_1_2_13_27_2","volume-title":"The Enteric Nervous System","author":"Furness J. B.","year":"2003"},{"key":"e_1_2_13_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012088394-3\/50028-3"},{"key":"e_1_2_13_29_2","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.0160-09.2009"},{"key":"e_1_2_13_30_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0707456104"},{"key":"e_1_2_13_31_2","first-page":"324","article-title":"Effects of rib raising on the autonomic nervous system: a pilot study using noninvasive biomarkers","volume":"110","author":"Henderson A. T.","year":"2010","journal-title":"Journal of the American Osteopathic Association"},{"key":"e_1_2_13_32_2","first-page":"122","volume-title":"Visceral Manipulation","author":"Barral J. P.","year":"1988"},{"key":"e_1_2_13_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2008.01110.x"},{"key":"e_1_2_13_34_2","doi-asserted-by":"publisher","DOI":"10.1179\/acb.2007.62.s1.011"},{"key":"e_1_2_13_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/humu.20935"},{"key":"e_1_2_13_36_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-870894"}],"container-title":["Case Reports in Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cripe\/2017\/5437830.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cripe\/2017\/5437830.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2017\/5437830","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T23:53:23Z","timestamp":1762473203000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2017\/5437830"}},"subtitle":[],"editor":[{"given":"Seyed Mohsen","family":"Dehghani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1155\/2017\/5437830"],"URL":"https:\/\/doi.org\/10.1155\/2017\/5437830","archive":["Portico"],"relation":{},"ISSN":["2090-6803","2090-6811"],"issn-type":[{"value":"2090-6803","type":"print"},{"value":"2090-6811","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"2016-11-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-01-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-01-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"5437830"}}